HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE ALR decreased the HMGB1/TLR4 signaling pathway in AP Mice. 29511434 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE Our data support the hypothesis that miR-21 modulates the inflammatory response during acute pancreatitis through the upregulation of Pias3 and downregulation of Hmgb1. 30537729 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE TNF-α, IL-6, IL-8, HMGB1 and Hsp70 during hospital admissions might serve to evaluate risk of death due to AP. 30947809 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE Compared with the AP group, the AP+PD98059+siRNA group had decreased expression of DUSP1 in tissues, whereas the AP+PD98059 group had decreased serum expression levels of TNF‑α, IL‑1β, IL‑6, HMGB1, S100A12 and amylase, lipase and urinary trypsinogen‑2. 29393354 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE The purpose of this meta-analysis was to comprehensively investigate the correlation between high mobility group box 1 (HMGB1) and interleukin-6 (IL-6) in relation to acute pancreatitis. 28618057 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE Changes of Serum Procalcitonin (PCT), C-Reactive Protein (CRP), Interleukin-17 (IL-17), Interleukin-6 (IL-6), High Mobility Group Protein-B1 (HMGB1) and D-Dimer in Patients with Severe Acute Pancreatitis Treated with Continuous Renal Replacement Therapy (CRRT) and Its Clinical Significance. 30136704 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE Dexamethasone inhibits NF‑кBp65 and HMGB1 expression in the pancreas of rats with severe acute pancreatitis. 30365121 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE A positive temporal link exists between early TAP activity and late HMGB1 expression in AP, and EP inhibits HMGB1 release. 28894846 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE Blockade of high-mobility group box 1 attenuates intestinal mucosal barrier dysfunction in experimental acute pancreatitis. 28754974 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE Association between high mobility group box‑1 protein expression and cell death in acute pancreatitis. 28440506 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE Our data suggest that HMGB1 regionally secreted by macrophages mediates pancreatic pain by targeting RAGE and CXCL12/CXCR4 axis in the early stage of acute pancreatitis. 28755135 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE A complex study of the plasma levels of HMGB1, sRAGE and circulating DNA can be informative in evaluations of acute pancreatitis with different levels of severity. 19451748 2009