|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of HMGB1 could be negatively regulated by HSF1, and the TLR4/MyD88/NF-κB signal pathway was involved in HSF1/HMGB1-mediated regulation of asthma.
|
31825792 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, these findings highlight that CuE can ameliorate human bronchial epithelial cell insult and inflammation under LPS-simulated asthmatic conditions by blocking the HMGB1-TLR4-NF-κB signaling, thereby supporting its usefulness as a promising therapeutic agent against asthma.
|
31525576 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results suggest that HMGB1 and RAGE are involved in the pathogenesis of asthma.
|
31003767 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A significantly elevation of HMGB1 protein expression and a reduction of miR-216a-5p expression were observed in children with asthma as well as in H₂O₂ stimulated 16HBE cells.
|
30502088 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sputum from subjects with asthma (n = 87) or COPD (n = 73) and ACO (n = 68) or from smokers (n = 62) and never-smokers (n = 62) was analyzed for high mobility group protein B1 (HMGB1), heat shock protein 70 (HSP70), LL-37, S100A8, and galectin-3 (Gal-3).
|
31848359 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results show TLR4 and HMGB1 both contribute to DINP-induced asthma, and that the inhibitions of TLR4 or HMGB1 offer potential means of treating asthma induced by phthalates like DINP.
|
31588340 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vitamin D reduces inflammatory response in asthmatic mice through HMGB1/TLR4/NF‑κB signaling pathway.
|
29257249 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the relationship between the ATP/P2X7-NLRP3 axis and HMGB1 in DCs in asthma is still unclear.
|
29545090 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, an OVA-induced asthma mouse model was set up and mice treated with anti-HMGB1 IgG.
|
29292841 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies demonstrated that HMGB1 (High mobility group box 1 protein) regulates airway inflammation and the Th2, Th17 inflammatory response in asthma.
|
29567318 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together all results found here, we may suggest HMGB1 is an important therapeutic target for asthma, once orchestrates the redox signaling, inflammation, and remodeling that contribute to the disease development.
|
28391514 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The area under the receiver operating characteristic curve, performed to define the diagnostic profile of sputum HMGB1 levels in identifying the children with asthma, was 0.713.
|
28441990 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An inverse and strict correlation between sputum HMGB1 levels and pulmonary function indices also were observed in children with mild (FEV1%, r = -0.86544, P < .0001; FEF25%-75%, r = -0.53948, P < .05), moderate (FEV1%, r = -0.99548, P < .0001; FEF25%-75%, r = -0.48668, P < .05), and severe (FEV1%, r = -0.90191, P < .0001; FEF25%-75%, r = -0.66777, P < .05) asthma.
|
26250770 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased abundance of HMGB1 is associated with several pathological disorders such as cancer, asthma and chronic obstructive pulmonary disease (COPD).
|
25726846 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sputum HMGB1 expressions were markedly higher in asthmatics than in normal controls, and were positively correlated with sputum eosinophilia and sputum TNF-α, IL-5 and IL-13 expressions.
|
22909167 |
2012 |