HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 AlteredExpression disease BEFREE Bioinformatics analysis demonstrated that HMGB1 was highly expressed in OA and activated PI3K/AKT pathway. 31712854 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE While in the late stage (24 and 48 h of LPS stimulation), the extracellular HMGB1 stimulated inflammation reaction and contributed to the cartilage destruction in OA. 31313630 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE Moreover, VA concentration -dependently inhibited IL-1β induced production of High-mobility group box 1 (HMGB1), a classic damage-associated molecular pattern (DAMP) molecule with strong pro-inflammatory effects in OA. 31228458 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE High-mobility group box 1 was negatively correlated with CCN3 in IL-1β-induced osteoarthritis responses, and HMGB1 is involved in the protective effect of CCN3 in OA. 31454155 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE The effect of chrysin (CH), a natural plant flavonoid, and its functional interaction with HMGB‑1, was investigated in a chondrocyte model of OA. 30535473 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 AlteredExpression disease BEFREE HMGB1 expression in OA tissue and OA chondrocytes was higher than in healthy specimens and cells. 30912672 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 AlteredExpression disease BEFREE The HMGB1 level was significantly lower in human OA cartilage than in normal cartilage. 29804557 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE Heparan sulfate has been shown to facilitate the binding of HMGB-1 to RAGE and could play a role in the progression of OA. 28474284 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE BRD4 has dual effects on the HMGB1 and NF-κB signalling pathways and is a potential therapeutic target for osteoarthritis. 28844955 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE But in this study, not only the expression of HMGB-1 in TMJ OA with disc perforation was investigated but also the possible role of HMGB-1 in TMJ OA was discussed. 26082301 2016
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE Furthermore, HMGB1 was spontaneously released from human OA-affected cartilage in ex vivo conditions. 24905701 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE Osteoarthritis synovial fibroblasts (OASFs) were co-cultured with HMGB1-LPS complex in vitro for five generations to induce the transformation of human SFs to RA-like SFs (tOASFs). 24556692 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 Biomarker disease BEFREE The distribution of HMGB1 in OA synovium was similar but the number of HMGB1 positive cells was higher and HMGB1 was also present in infiltrated cells. 20799933 2010
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 AlteredExpression disease BEFREE HMGB-1 concentrations were significantly higher in SF of RA patients than in that of OA patients. 12687539 2003