HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Disease: Liver Failure, Acute ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE The HMGB1 inhibitor GLY significantly reduced the degree of ferroptosis during ALF by inhibiting oxidative stress. 31545489 2019
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen. 30979951 2019
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE Hemoadsorption of high-mobility-group box 1 using a porous polymethylmethacrylate fiber in a swine acute liver failure model. 29528759 2018
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE Expert commentary: HMGB1 could be a novel therapeutic candidate for ALF, and the clinical testing of HMGB1-targeting therapies for ALF patients is expected. 28657371 2017
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE Therefore, HMGB1 seems to be an important factor that links BT and systemic inflammation in ALF. 28694564 2017
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE Next, kinetic monitoring sera HMGB1 revealed elevated HMGB1 in progression stage of ALF vs HBsAg carrier, and drop back to base level in remission stage. 25388426 2015
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 Biomarker disease BEFREE HMGB1 box-A gene transfer results in box-A protein production in the liver and appears to have a beneficial effect on ALF in rats. 25498512 2015
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.080 AlteredExpression disease BEFREE The aim of present study was to determine the role of the intracellular high-mobility group box 1 (HMGB1) in modulating the early activation of KCs during ALF. 23706499 2013