Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease BEFREE Concomitant inhibition of FASN-mediated FA synthesis and HMGCR-driven cholesterol production was highly detrimental for HCC cell growth in culture. 30954949 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease BEFREE HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma. 30483734 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 AlteredExpression disease BEFREE Likewise, knockdown of HMGCR reduced FoxM1 expression, indicating that FoxM1 expression was regulated by the mevalonate pathway in HCC. 29765517 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease CTD_human Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. 21147110 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease CTD_human Protein and messenger RNA (mRNA) levels for both G6PD and malic enzyme increased in hyperplastic livers and HCC. mRNA levels for 3-hydroxy-3-methylglutaryl-coenzyme A reductase decreased in hyperplasia and increased in HCC, whereas low-density lipoprotein receptor mRNA increased in hyperplasia and decreased in HCC. 9207284 1997
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease BEFREE We have carried out parallel analyses of the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGr) and low density lipoprotein receptor (LDLr) in two highly differentiated human hepatoma cell lines, HepG2 and Hep3B, and primary cultures of human fibroblasts. 1653247 1991