HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 AlteredExpression phenotype BEFREE Taken together, our findings reveal a novel mechanism by which Nrf2/HO-1/CO mediates Cx43 expression in vincristine-induced neuropathic pain. 31617070 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 AlteredExpression phenotype BEFREE The administration of UFP-512 increased/reestablished the spinal cord protein levels of Nrf2 and HO-1 in mice with inflammatory or neuropathic pain. 30971925 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. 31060340 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE The inhibition of microglial activation and induction of the Nrf2/HO-1/NQO1 signaling pathway in the hippocampus and/or prefrontal cortex may explain the antidepressant effects of oltipraz during neuropathic pain. 31234342 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 AlteredExpression phenotype BEFREE Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain. 29247614 2018