HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Disease: Tumor Initiation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598935
Disease: Tumor Initiation
Tumor Initiation 		0.020 Biomarker phenotype BEFREE We further showed that HO-1-driven expression of E-cadherin in cancer cells cultured in the presence of macrophages is dependent on mitochondrial activity of cancer cells.In summary, these data suggest that HO-1-derived CO from tumor-associated macrophages influences, in part, E-cadherin expression and thus tumor initiation and progression. 26418896 2015
CUI: C0598935
Disease: Tumor Initiation
Tumor Initiation 		0.020 Biomarker phenotype BEFREE Heme oxygenase-1 (HO-1, HMOX1) can prevent tumor initiation; while in various tumors, it has been demonstrated to promote growth, angiogenesis, and metastasis. 23617628 2013