HMOX1, heme oxygenase 1, 3162

N. diseases: 137; N. variants: 3
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.700 Biomarker disease CTD_human
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Therapeutic disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Therapeutic disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker disease CTD_human Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Therapeutic disease CTD_human Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002
CUI: C0009319
Disease: Colitis
Colitis 		0.570 Therapeutic disease CTD_human An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. 21444764 2011
CUI: C0009319
Disease: Colitis
Colitis 		0.570 Therapeutic disease CTD_human Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. 16365149 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.560 Biomarker disease CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker disease CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.520 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Therapeutic disease CTD_human Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. 25780291 2015
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker disease CTD_human Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. 25780291 2015
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker disease CTD_human Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1. 23075401 2013
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Therapeutic disease CTD_human Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1. 23075401 2013
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.510 Biomarker disease CTD_human Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE. 20971094 2011
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Therapeutic disease CTD_human Cobalt protoporphyrin (CoPP) was administered IP at 10 or 20mg/kg 24h before IRI, to induce HO-1 upregulation.Control animals received vehicle alone. 17660127 2007
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker disease CTD_human Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats. 17906103 2007