HMOX2, heme oxygenase 2, 3163

N. diseases: 31; N. variants: 4
Disease: Restless Legs Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.020 Biomarker disease BEFREE The effects of HMOX1 and HMOX2 gene on developing RLS were not seen after the inclusion of RLS patients with a low ferritin level. 31063999 2019
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.020 GeneticVariation disease BEFREE We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS.We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls.The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. 26313808 2015