|
Cerebral Hemorrhage
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage.
|
16459095 |
2006 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the single-nucleotide polymorphisms (SNPs) rs2071746 and rs2071747 in HMOX1 and rs1051308 in HMOX2 in 583 Han Chinese with PD and 627 healthy controls using a customized 2×48-Plex SNP Scan™ kit.
|
28179208 |
2017 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Several reports suggested a role of heme oxygenase genes 1 and 2 (HMOX1 and HMOX2) in modifying the risk to develop Parkinson disease (PD).
|
26091465 |
2015 |
|
Parkinson Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We describe for the first time, copy number variations in the HMOX2 gene and an association of the SNP rs2270363 with PD risk.
|
21709601 |
2011 |
|
Restless Legs Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The effects of HMOX1 and HMOX2 gene on developing RLS were not seen after the inclusion of RLS patients with a low ferritin level.
|
31063999 |
2019 |
|
Essential Tremor
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET.
|
28276576 |
2017 |
|
Restless Legs Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS.We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls.The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls.
|
26313808 |
2015 |
|
Essential Tremor
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests a weak association between HMOX1 rs2071746 and HMOX2 rs1051308 polymorphisms and the risk to develop ET in the Spanish population.
|
26091465 |
2015 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
HO-1 protein levels were significantly increased in the hippocampus of AD subjects, whereas HO-2 protein levels were significantly decreased in both AD and MCI hippocampi.
|
22549002 |
2012 |
|
Age related macular degeneration
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the 19G>C-HMOX1 and the -42 + 1444A>G-HMOX2 polymorphisms may be associated with the occurrence and progression of AMD.
|
21647550 |
2012 |
|
Age related macular degeneration
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In the present work we analyzed the association between the c.544G>A polymorphism of the heme oxygenase-2 gene (HMOX2) (rs1051308) and AMD.
|
21804464 |
2011 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our study failed to detect any association between the SNPs of the HMOX1 and HMOX2 genes and AD.
|
19246912 |
2009 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice.
|
31436967 |
2019 |
|
Keratoconus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The HO-2 enzyme may play a role in the etiopathogenesis of keratoconus.
|
30196728 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex.
|
31215802 |
2019 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice.
|
31436967 |
2019 |
|
Myxoid cyst
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR and Western blot analyses on days 7 and 14, revealed that treatment with CORM-2-SLNs resulted in greater reductions in the CCI-elevated levels of heme-oxygenase-2 (HO-2); inducible nitric oxide synthase (iNOS); neuronal NOS (nNOS); and inflammatory mediators (TNF-α, IBA-1, and GFAP) in the spinal cord and dorsal root ganglions compared with treatment with CORM-2.
|
30637664 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice.
|
31436967 |
2019 |
|
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia.
|
30087547 |
2018 |
|
Hyperemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Under normoxia, blood flow velocity in precapillary arterioles were significantly elevated in heme oxygenase-2-null mice vs controls, while metabolic intermediates of central carbon metabolism and glutamate synthesis were elevated in the brain of heme oxygenase-2-null mice, suggesting greater metabolic demands to induce hyperemia in these mice.
|
30087547 |
2018 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aims to examine whether heme oxygenase-2 plays a protective role in mice against stroke.
|
30087547 |
2018 |
|
Sleep Apnea Syndromes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we report that mice deficient in heme oxygenase-2 (HO-2), which generates the gaseous molecule carbon monoxide (CO), exhibit sleep apnea characterized by high apnea and hypopnea indices during rapid eye movement (REM) sleep.
|
28115703 |
2017 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gene expressions (HMOX1, HMOX2, BLVRA) and HCV RNA were analyzed in PBL of HCV treatment naïve patients (n = 58) and controls (n = 55), with a subset of HCV patients having data on hepatic gene expression (n = 35).
|
23536765 |
2013 |
|
Mild cognitive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HO-1 protein levels were significantly increased in the hippocampus of AD subjects, whereas HO-2 protein levels were significantly decreased in both AD and MCI hippocampi.
|
22549002 |
2012 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension.
|
19886851 |
2009 |