|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
In particular, members of the Wnt and TGF-beta pathways, pro-apoptotic genes such as APAF-1 and negative cell-cycle regulators such as KILLIN have been shown to be epigenetically silenced in numerous studies in ccRCC.
|
26198328 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the occurrence and relevance of promoter methylation of the tumor suppressor DAPK-1, APAF-1 () and SPARC in relation to different pathological stages and histological grades of tumor progression that might act as possible independent prognostic factor in the susceptibility towards renal cell carcinoma (RCC) in North Indian population.
|
21922274 |
2012 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.340 |
PosttranslationalModification
|
disease |
BEFREE |
The APAF-1 methylation levels in RCC were significantly higher in tumours larger than 4 cm and in high-grade tumours.
|
17133271 |
2006 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In multivariate analysis, APAF-1 and DAPK-1 methylation levels were independent prognostic markers for metastatic disease and death from renal cell carcinoma.
|
16951219 |
2006 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
The APAF-1 methylation levels in RCC were significantly higher in tumours larger than 4 cm and in high-grade tumours.
|
17133271 |
2006 |
|
Renal Cell Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the occurrence and relevance of promoter methylation of the tumor suppressor DAPK-1, APAF-1 () and SPARC in relation to different pathological stages and histological grades of tumor progression that might act as possible independent prognostic factor in the susceptibility towards renal cell carcinoma (RCC) in North Indian population.
|
21922274 |
2012 |
|
Renal Cell Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype.
|
17945286 |
2007 |
|
Renal Cell Carcinoma
|
0.330 |
Biomarker
|
disease |
LHGDN |
Our findings indicate that promoter hypermethylation of APAF-1 and DAPK-1 is a marker of aggressive renal cell carcinoma and provides independent prognostic information on disease outcome.
|
16951219 |
2006 |
|
Renal Cell Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer.
|
17133271 |
2006 |
|
Renal Cell Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In multivariate analysis, APAF-1 and DAPK-1 methylation levels were independent prognostic markers for metastatic disease and death from renal cell carcinoma.
|
16951219 |
2006 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Rare apoptosis-promoting functional variants in the apoptosis protease activating factor 1 (APAF1) gene were recently reported to co-segregate with major depression in male members of families from Utah.
|
19455599 |
2010 |
|
Unipolar Depression
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Rare apoptosis-promoting functional variants in the apoptosis protease activating factor 1 (APAF1) gene were recently reported to co-segregate with major depression in male members of families from Utah.
|
19455599 |
2010 |
|
Major Depressive Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These results show that the APAF1 variants associated with risk for MDD in the Utah pedigrees are very rare in Northern European and European-American populations.
|
19455599 |
2010 |
|
Major Depressive Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results show that the APAF1 variants associated with risk for MDD in the Utah pedigrees are very rare in Northern European and European-American populations.
|
19455599 |
2010 |
|
Carcinoma, Transitional Cell
|
0.320 |
PosttranslationalModification
|
disease |
BEFREE |
The aim of our study was to investigate a potential link between EZH2 mRNA expression and the extent of APAF-1, DAPK-1 and IGFBP-3 methylation in urothelial transitional cell carcinoma (TCC) and to correlate the data with histopathological parameters and follow-up data.
|
17541304 |
2007 |
|
Carcinoma, Transitional Cell
|
0.320 |
Biomarker
|
disease |
BEFREE |
To examine the significance of the methylation level of the p53 target and tumour suppressor genes apoptotic protease activating factor-1 (APAF-1) and death-associated protein kinase-1 (DAPK-1) in 80 microdissected tumour samples from transitional cell carcinoma (TCC) of the bladder and 80 tumour samples from clear-cell renal cell carcinoma (RCC) as well as from non-tumourous bladder and kidney tissue.
|
17133271 |
2006 |
|
Carcinoma, Transitional Cell
|
0.320 |
Biomarker
|
disease |
CTD_human |
To examine the significance of the methylation level of the p53 target and tumour suppressor genes apoptotic protease activating factor-1 (APAF-1) and death-associated protein kinase-1 (DAPK-1) in 80 microdissected tumour samples from transitional cell carcinoma (TCC) of the bladder and 80 tumour samples from clear-cell renal cell carcinoma (RCC) as well as from non-tumourous bladder and kidney tissue.
|
17133271 |
2006 |
|
Unipolar Depression
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.
|
16231040 |
2006 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.
|
16231040 |
2006 |
|
Major Depressive Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.
|
16231040 |
2006 |
|
Major Depressive Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems.
|
16231040 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Retinal Detachment
|
0.300 |
Biomarker
|
disease |
CTD_human |
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.
|
18497877 |
2008 |
|
Retinal Pigment Epithelial Detachment
|
0.300 |
Biomarker
|
disease |
CTD_human |
HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.
|
18497877 |
2008 |
|
Chromophobe Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer.
|
17133271 |
2006 |