HNF4A, hepatocyte nuclear factor 4 alpha, 3172

N. diseases: 340; N. variants: 74
Disease: Renal Cell Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 PosttranslationalModification disease BEFREE Silencing of tumor-suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency. 31432508 2020
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 Biomarker disease BEFREE These findings may provide novel insights into the biological effects of HNF‑4α and lay the foundation for the discovery of molecular therapeutic targets in RCC. 31322246 2019
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 AlteredExpression disease BEFREE Genistein also decreased TCF reporter activity in RCC cells. 23591200 2013
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 Biomarker disease BEFREE The cell-specific transcription factor hepatocyte nuclear factor 4 alpha (HNF4 alpha) is down-regulated in RCC and we have shown that HNF4 alpha inhibits cell proliferation in the embryonic kidney cell line HEK293. 18163890 2008
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 Biomarker disease BEFREE These genes (ACY1, WT1, SELENBP1, COBL, EFHD1, AGXT2L1, ALDH5A1, THEM2, ABCB1, FLJ14146, CSPG2, TRIM9 and HEY1) are good candidates for genes whose activity is changed upon the decrease of HNF4alpha in RCC. 16007190 2005
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.150 Biomarker disease HPO