|
Birth Weight
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
|
31043758 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Hepatocyte nuclear factor 6 (HNF6), as a transcription factor, has been reported to be involved in cell proliferation, carcinogenesis, and tumor metastasis.
|
30256389 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
HNF6 promoted CRC cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis.
|
30256389 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.030 |
Biomarker
|
disease |
BEFREE |
HNF6 promoted CRC cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis.
|
30256389 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
This study sought to investigate the role of HNF6, particularly the molecular mechanisms for how HNF6 is involved in the growth and metastasis of cholangiocarcinoma (CCA) cells.
|
26825606 |
2016 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The results indicate that HNF6 may serve as a tumor suppressor by regulating miR-122, and its overexpression may represent a mechanism-based therapy for CCA.
|
26825606 |
2016 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Potential tumor suppressors (FoxA3 and Onecut1) and oncogenes (MAFG and SSX1) were functionally validated.
|
24798046 |
2014 |
|
Secondary malignant neoplasm of liver
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Recently, we demonstrated that the transcription factors HNF6 and FOXA2 function as key regulators in human colorectal liver metastases.
|
20967225 |
2010 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
LHGDN |
For its known interaction with HNF6, we investigated expression of FOXA2, which we found to be specifically induced in colorectal liver metastases.
|
17283222 |
2007 |
|
Secondary malignant neoplasm of liver
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
For its known interaction with HNF6, we investigated expression of FOXA2, which we found to be specifically induced in colorectal liver metastases.
|
17283222 |
2007 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The xenograft model was used to assess the effects of HNF6 overexpression on tumorigenesis, growth, metastasis and therapeutic potentials.
|
26825606 |
2016 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Reduced KLF4 or HNF6 expression correlated with high HCC grade.
|
26338995 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In the top cancer-associated category, HIF1A, IL8, TERT, ONECUT1, and FOXA1 directly interacted with either transcription factors or cytokines that are known to be involved in the tumorigenesis or metastasis of other malignant tumors.
|
25034661 |
2014 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Human hepatoma (HepG2) cotransfection assays demonstrated that HNF-6 synergistically stimulated FoxA2 but not FoxA1 or FoxA3 transcriptional activity, and protein-binding assays showed that this protein interaction required the HNF-6 Cut-Homeodomain and FoxA2 winged-helix DNA binding domains.
|
12509444 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We screened HNF-6 gene for mutations in 34 Japanese subjects with MODY/early-onset diabetes mellitus and 56 subjects with late-onset diabetes mellitus.
|
11323086 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the coding region of the HNF-6 gene are not associated with Type II diabetes or with changes in insulin responses to glucose among the Caucasians examined.
|
10491763 |
1999 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HNF6 promoted CRC cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis.
|
30256389 |
2019 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Hepatocyte nuclear factor 6 (HNF6), as a transcription factor, has been reported to be involved in cell proliferation, carcinogenesis, and tumor metastasis.
|
30256389 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model.
|
30256389 |
2019 |
|
Biliary Atresia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GATA6 expression in BA livers correlates with expression of known regulators of cholangiocyte differentiation ( JAGGED1, HNF1β, and HNF6).
|
29388792 |
2018 |
|
Congenital atresia of extrahepatic bile duct
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GATA6 expression in BA livers correlates with expression of known regulators of cholangiocyte differentiation ( JAGGED1, HNF1β, and HNF6).
|
29388792 |
2018 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6.
|
26338995 |
2016 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study sought to investigate the role of HNF6, particularly the molecular mechanisms for how HNF6 is involved in the growth and metastasis of cholangiocarcinoma (CCA) cells.
|
26825606 |
2016 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study sought to investigate the role of HNF6, particularly the molecular mechanisms for how HNF6 is involved in the growth and metastasis of cholangiocarcinoma (CCA) cells.
|
26825606 |
2016 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Restored HNF-6 expression upregulated expression of differentiation-associated markers and inhibited HCC cell migration and invasion, whereas HNF-6 knockdown did the opposite.
|
26338995 |
2016 |