NUDT2, nudix hydrolase 2, 318

N. diseases: 16; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.310 Biomarker disease CTD_human Previous studies demonstrated its regulation through estrogens, suggesting possible importance of NUDT2 in breast carcinoma. 20533549 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.310 Biomarker disease BEFREE Previous studies demonstrated its regulation through estrogens, suggesting possible importance of NUDT2 in breast carcinoma. 20533549 2011
CUI: C0026827
Disease: Muscle hypotonia
Muscle hypotonia 		0.300 Biomarker phenotype GENOMICS_ENGLAND A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children. 30059600 2018
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.300 Biomarker disease GENOMICS_ENGLAND A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children. 30059600 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.300 Biomarker group GENOMICS_ENGLAND A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children. 30059600 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 Biomarker disease CTD_human Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation. 20533549 2011
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation. 20533549 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.300 Biomarker group CTD_human Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation. 20533549 2011
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker disease CTD_human Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation. 20533549 2011
CUI: C0024530
Disease: Malaria
Malaria 		0.010 Biomarker disease BEFREE Using the rodent malaria parasite Plasmodium berghei we evaluate here, by gene targeting, a group of conserved proteins with a putative function in the detoxification of non-canonical nucleotides as potential antimalarial drug targets: they are inosine triphosphate pyrophosphatase (ITPase), deoxyuridine triphosphate pyrophosphatase (dUTPase) and two NuDiX hydroxylases, the diadenosine tetraphosphate (Ap4A) hydrolase and the nucleoside triphosphate hydrolase (NDH). 30700216 2019
CUI: C1535926
Disease: Neurodevelopmental Disorders
Neurodevelopmental Disorders 		0.010 GeneticVariation group BEFREE A founder nonsense variant in NUDT2 causes a recessive neurodevelopmental disorder in Saudi Arab children. 30059600 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Regardless, our results suggest that the NUDT2 protein could be a novel cancer chemotherapeutic target, with its inhibition potentially exerting strong anti-tumor effects via multiple pathways involving metastasis, invasion, immunosuppression and apoptosis. 27144453 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Regardless, our results suggest that the NUDT2 protein could be a novel cancer chemotherapeutic target, with its inhibition potentially exerting strong anti-tumor effects via multiple pathways involving metastasis, invasion, immunosuppression and apoptosis. 27144453 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE Regardless, our results suggest that the NUDT2 protein could be a novel cancer chemotherapeutic target, with its inhibition potentially exerting strong anti-tumor effects via multiple pathways involving metastasis, invasion, immunosuppression and apoptosis. 27144453 2016
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.010 Biomarker disease BEFREE NUDT2 immunoreactivity was detected in 78% of DCIS and 63% of IDC, and NUDT2 mRNA level was significantly higher in DCIS or IDC than non-neoplastic breast. 20533549 2011
CUI: C1134719
Disease: Invasive Ductal Breast Carcinoma
Invasive Ductal Breast Carcinoma 		0.010 Biomarker disease BEFREE Immunohistochemistry for NUDT2 was examined by invasive ductal carcinoma (IDC: n = 145) and pure ductal carcinoma in situ (DCIS: n = 82), and NUDT2 mRNA was examined by real-time PCR in 9 DCIS, 19 IDC and 6 non-neoplastic breast tissues. 20533549 2011
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.010 Biomarker disease BEFREE NUDT2 status was significantly associated with adverse clinical outcome of IDC patients and proved an independent prognostic factor. 20533549 2011