HOXA10, homeobox A10, 3206

N. diseases: 122; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 AlteredExpression disease BEFREE The expression of HOXA10 was detected by Immunofluorescence staining in endometrial cancer tissues and adjacent normal tissues. 29618950 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 AlteredExpression disease BEFREE The expression of lncRNA H19 and HOXA10 was high in endometrial carcinoma and miR-612 was lowly expressed. 30070313 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 AlteredExpression disease BEFREE Expression of HOXA10 and p21 gene decreased in endometrial cancer, and the expression level of HOXA10 was correlated with cancer grade. 24943991 2014
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 Biomarker disease CTD_human The expression of HOXA10 was deregulated in endometrial carcinomas and up-regulated by sex hormones. 21670700 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 AlteredExpression disease BEFREE The expression of HOXA10 was deregulated in endometrial carcinomas and up-regulated by sex hormones. 21670700 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.350 Biomarker disease BEFREE These findings reveal a novel role for HOXA10 deregulation in the progression of endometrial carcinoma by promoting epithelial-mesenchymal transition. 16424022 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease BEFREE Thus, the function of HoxA10 is similar to the action of interferon (IFN) in terms of inhibition of HBV infection; however, the mechanism of HoxA10-mediated repression of HBV replication is different from the mechanism underlying IFN-induced inhibition of HBV infection.<b>IMPORTANCE</b> Two billion people have been infected with HBV worldwide; about 240 million infected patients developed chronic hepatitis B (CHB), and 650,000 die each year from liver cirrhosis (LC) or hepatocellular carcinoma (HCC). 30674631 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease BEFREE RNA interference-mediated knockdown of HOXA10 inhibited HCC cell proliferation both in vitro and in vivo. 31440094 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease BEFREE Bioinformatic method was applied to predict the binding of miR-218 on HoxA10, and western blotting was used to examine the modulatory effect of miR-218 AND HoxA10 on PTEN/AKT/PI3K pathway in HCC. 25120782 2014
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.330 Biomarker group CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.330 Biomarker group BEFREE Furthermore, methylation of PENK, BCL2, RUNX3, DLEC1, MT1G, GRIN2B, CDH13, CCND2, and HOXA10 was significantly more frequent in invasive ADC than AAH or AIS. 21494759 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.330 AlteredExpression group BEFREE Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.330 AlteredExpression group BEFREE HOXA10 expression is elevated in high nuclear grade stage I and II endometrial adenocarcinomas. 15627890 2005
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms
0.310 Biomarker group CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms
0.310 Biomarker group LHGDN Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. 16424022 2006
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell
0.300 Biomarker disease CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic
0.300 Biomarker disease CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0205643
Disease: Carcinoma, Cribriform
Carcinoma, Cribriform
0.300 Biomarker disease CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0205644
Disease: Carcinoma, Granular Cell
Carcinoma, Granular Cell
0.300 Biomarker disease CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular
0.300 Biomarker disease CTD_human Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. 21670700 2011
CUI: C1720887
Disease: Female Urogenital Diseases
Female Urogenital Diseases
0.300 Biomarker group CTD_human Development of the mammalian female reproductive tract. 16002989 2005
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.100 AlteredExpression disease BEFREE Since it is well known that aberrant expression of HOXA10 is involved in pathogenesis of the endometrium, our data emphasized the epigenetic role of this gene aberration related to clinical pathophysiology of endometriosis. 29592776 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE This study provides human and mouse evidence to suggest tumor suppressive roles for HOXA10 in the context of prostate cancer. 30614022 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Upregulated HOXA10 promoted GC cell proliferation with reduced apoptosis in vitro and accelerated GC tumor growth in vivo. 31364281 2019