|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since it is well known that aberrant expression of HOXA10 is involved in pathogenesis of the endometrium, our data emphasized the epigenetic role of this gene aberration related to clinical pathophysiology of endometriosis.
|
29592776 |
2019 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we found that a member of the calcium (Ca<sup>2+</sup>)-dependent cysteine protease family calpain7 (CAPN7), negatively correlated with HOXA10, was highly expressed in the endometrium of infertile women with ENDO and was significantly downregulated during the window of embryo implantation in mice.
|
29459744 |
2018 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most tested autophagic biomarker proteins and mRNAs were upregulated, whereas HOXA10 protein and mRNA were decreased in ovarian endometriomas compared with eutopic endometria of women with endometriosis and normal endometria.
|
29658437 |
2018 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of HOXA10 and HOXA11 in the EU were significantly lower in women with peritoneal endometriosis compared to the control group participants ( P < .05), whereas the levels of lncRNA ( HOXA11-AS1), HOXA9, and HOXA13 did not differ significantly between the 2 patient groups ( P > .05).
|
29017417 |
2018 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first study investigating the methylation of HOXA10 and COMT genes and their linkage to endometriosis in Chinese patients.
|
28074437 |
2017 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HOXA10 gene in women with endometriosis was hypomethylated compared to controls.
|
26865543 |
2016 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx.
|
26552702 |
2015 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the HOXA10 gene, which is important for successful implantation, is reduced in women affected by endometriosis.
|
24963168 |
2014 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ChIP analysis showed hypoacetylation of H3/H4 within promoter regions of candidate genes known to be downregulated in endometriosis (e.g., HOXA10, ESR1, CDH1, and p21 (WAF1/Cip1) ) in lesions versus control endometrium.
|
23899551 |
2014 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
If vitamin D and its metabolites are implicated in endometriosis-associated infertility, it is likely through interference with HOXA10 gene expression.
|
24135500 |
2014 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that the level of HOXA10 decrease in the eutopic endometrium of patients with endometriosis.
|
22915150 |
2013 |
|
Endometriosis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Promoter hypermethylation of HOXA10 is thought to be the leading mechanism for epigenetic gene regulation in patients with endometriosis.
|
24032603 |
2013 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We evaluated miR135a/b expression and HOXA10 regulation in endometrium from subjects with and without endometriosis.
|
21956427 |
2011 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Coding regions of INHBA, SFRP4 and HOXA10 are not implicated in familial endometriosis linked to chromosome 7p13-15.
|
21576276 |
2011 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We confirmed that DNA hypermethylation can be one of the potential molecular mechanisms silencing HOXA10 expression in the midluteal endometrium associated with infertility in women with endometriosis.
|
20971605 |
2010 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Marked expression of HOXA-10 and HOXA-13 in the endometrium-like tissue of nodules but low expression in peritoneal endometriotic lesions supports the theory of differential origin of these two types of endometriosis.
|
20171623 |
2010 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HOXA10 hypermethylation has recently been demonstrated to silence HOXA10 gene expression and account for decreased HOXA10 in the endometrium of women with endometriosis.
|
20104430 |
2010 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Women with endometriosis do not demonstrate the expected mid-luteal rise of HOXA10 expression, which might partially explain the infertility observed in many of these patients.
|
20821045 |
2010 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One of the underlying causes of infertility in patients with only superficial endometriosis may be altered expression of HOXA-10 in endometrial stromal cells.
|
19736237 |
2009 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The endometrium from women with endometriosis also showed decreased expression of OPN in the late secretory phase and LPA3 and HOXA10 expression in the midsecretory and late secretory phases.
|
18672236 |
2009 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were 7.23% patients with HOXA10 genetic alterations; however, there was no significant increase in the endometriosis patients compared with the controls.
|
18339267 |
2008 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
There were 7.23% patients with HOXA10 genetic alterations; however, there was no significant increase in the endometriosis patients compared with the controls.
|
18339267 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we identified Calpain5 as a target of HOXA10 transcriptional regulation in endometrial cells as well as its aberrant regulation in endometriosis.
|
18829447 |
2008 |
|
Endometriosis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This, in conjunction with our reported aberrant methylation of HOXA10 in the eutopic endometrium of women with endometriosis, strongly suggests that endometriosis is an epigenetic disease.
|
17965625 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The F1 region on the promoter was found to be the most significantly methylated in the endometriosis animals and this may account for the decrease in HOXA10 expression.
|
17350963 |
2007 |