|
Trichotillomania
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
Hoxb8 mutant mice exhibit compulsive grooming and hair removal dysfunction similar to humans with the obsessive-compulsive disorder (OCD)-spectrum disorder, trichotillomania.
|
28948967 |
2018 |
|
Trichotillomania
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania.
|
20510925 |
2010 |
|
Trichotillomania
|
0.520 |
Biomarker
|
disease |
CTD_human |
Hoxb8 is required for normal grooming behavior in mice.
|
11779477 |
2002 |
|
Trichotillomania
|
0.520 |
Biomarker
|
disease |
MGD |
Hoxb8 is required for normal grooming behavior in mice.
|
11779477 |
2002 |
|
Obsessive-Compulsive Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Our results shed light on Hoxb8 microglia-driven circuit-specific defects and therapeutic approaches that will become essential to developing novel therapies for neuropsychiatric diseases such as OCD and ASDs with Hoxb8-microglia being the central target.
|
28948967 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania.
|
20510925 |
2010 |
|
Obsessive-Compulsive Disorder
|
0.320 |
Biomarker
|
disease |
CTD_human |
Hoxb8 is required for normal grooming behavior in mice.
|
11779477 |
2002 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Mechanistically, HOXB8 interacted with a key metastasis regulator BACH1 and instigated BACH1-mediated transcriptional cascade by directly occupying and activating BACH1 gene transcription together with BACH1 itself.
|
31591481 |
2020 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo.
|
30622439 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
LINC01006 promotes cell proliferation and metastasis in pancreatic cancer via miR-2682-5p/HOXB8 axis.
|
31827394 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the findings of the present study demonstrated that knockdown of HOXB8 could suppress tumorigenesis and metastasis in OS through regulation of the Wnt/β-catenin signaling pathway.
|
30954562 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of HOXB8 also increases the rate of metastasis in NCI-N87 mice, while silencing HOXB8 has the opposite results.
|
27761656 |
2017 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo.
|
30622439 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In addition, knockdown of HOXB8 dramatically repressed the migration and invasion of OS cells.
|
30954562 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
This study was designed to investigate the mechanism of HOXB8 regulating colorectal cancer cell proliferation and invasion in vivo and in vitro.
|
30677006 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of HOXB8 can promote gastric cancer cells migration and invasion, while silencing HOXB8 leads to the opposite results.
|
27761656 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Lastly, the relevance of HOXB8 activation in clinical settings was strengthened by its close association with prognostic outcomes of CRC patients.
|
31591481 |
2020 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study was designed to investigate the mechanism of HOXB8 regulating colorectal cancer cell proliferation and invasion in vivo and in vitro.
|
30677006 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results indicate that HOXB8 may be an independent prognostic factor in CRC.Therefore, deserved a deeper research.
|
30622439 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Knockdown of HOXB8 inhibits tumor growth and metastasis by the inactivation of Wnt/β-catenin signaling pathway in osteosarcoma.
|
30954562 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Data mining of publicly accessible RNA sequence datasets and our patient cohorts confirmed a higher expression of HOXB8 in the tumor tissue of GBM patients, and a strong positive correlation between the expression level and pathological grading of tumors and a negative correlation between the expression level and the overall survival rate.
|
31646435 |
2019 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo.
|
30622439 |
2019 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, the findings of the present study demonstrated that knockdown of HOXB8 could suppress tumorigenesis and metastasis in OS through regulation of the Wnt/β-catenin signaling pathway.
|
30954562 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Recent data which suggest a regulatory link between HOXB8 and several tumor suppressor genes, such as DCC, APC, and TGF beta, sustain a possible implication of homeobox genes in colon carcinogenesis.
|
9126347 |
1997 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Recent data which suggest a regulatory link between HOXB8 and several tumor suppressor genes, such as DCC, APC, and TGF beta, sustain a possible implication of homeobox genes in colon carcinogenesis.
|
9126347 |
1997 |