|
Malignant tumor of colon
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer.
|
1310068 |
1992 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-resolution banding studies indicated that the deletion in the patient with polyposis spans the region 5q21-q22, which includes APC, a gene involved in familial adenomatous polyposis and sporadic colon cancer.
|
1315124 |
1992 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers.
|
1355210 |
1992 |
|
Malignant tumor of colon
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
They imply that inactivation of APC, MCC, and/or a linked gene on chromosome 5q plays a role in the pathogenesis of some cancers of the upper gastrointestinal tract, as well as in colon cancer and familial adenomatous polyposis.
|
1565631 |
1992 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
7846077 |
1995 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The APC gene, mutations in which are responsible for the inherited colon cancer syndrome adenomatous polyposis coli (APC), is described as a tumor suppressor gene.
|
7882361 |
1995 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer.
|
7903889 |
1993 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer.
|
8381581 |
1993 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A database is described in which over 700 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature.
|
8594558 |
1996 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic alterations in rat colon tumors induced by heterocyclic amines.
|
8608549 |
1996 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers.
|
8990193 |
1997 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, we did not detect any functional mutations of the APC gene in a wide variety of tumors except for a colon cancer cell line, suggesting that alterations of the APC gene do not have a major role in the development of lung and renal cancers, various types of sarcomas, or hematological malignancies.
|
9083931 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
The APC/MCC gene (Familial Adenomatous Polyposis) at 5q21 plays a role in colon cancer carcinogenesis.
|
9182290 |
1996 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations.
|
9196022 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Colon cancer. Molecular biology of the APC protein.
|
9296069 |
1997 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this model may have some relevance and application to the study of colon cancer in human inflammatory bowel disease, which is not associated with APC mutations or with Ki-ras or p53 mutations.
|
9433483 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Peptide-mediated precipitation experiments showed that anti-APCp1 bound and sequestered wild-type and mutant APC proteins in extracts of human colon cancer cell lines.
|
9663391 |
1998 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer.
|
10090594 |
1999 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutant forms of beta-catenin have been discovered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, prostate cancer and gastric and hepatocellular carcinomas.
|
10201372 |
1999 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.
|
10383901 |
1999 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC-beta-catenin pathway are common in colon cancer.
|
10507776 |
1999 |