|
Malignant tumor of colon
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Colon cancer. Molecular biology of the APC protein.
|
9296069 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
APC immunoreactivity was absent in all of the mouse adenocarcinomas and 83% of the human colon cancers.
|
11062151 |
2000 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APC mutations were associated with poor prognosis in (5-fluorouracil treated) stage III colon cancers (p = 0.005; HR = 4.1), an effect that was further enhanced by mutations in MAPK pathway (KRAS, NRAS, BRAF) genes.
|
27729614 |
2016 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.
|
28576136 |
2017 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A database is described in which over 700 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature.
|
8594558 |
1996 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrome), and APC and beta-catenin point mutations occur in up to 10% of sporadic cases, indicating the involvement of the Wnt pathway in the development of medulloblastoma.
|
12555076 |
2003 |
|
Malignant tumor of colon
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Among 10 FZD gene family members, FZD7 mRNA was predominantly expressed in six colon cancer cell lines with APC or CTNNB1 mutation.
|
18592008 |
2008 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An in vitro-derived "TAK1 dependency signature" is enriched in primary human colon cancers with mutations in both APC and KRAS, suggesting potential clinical utility in stratifying patient populations.
|
22341439 |
2012 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into colon cancer.
|
30256815 |
2018 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention.
|
21885812 |
2011 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes.
|
17192441 |
2007 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conventional adenomas arise from mutation of the APC gene; progression to colon cancer is a multistep process.
|
18313537 |
2008 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated human colon cancers and Apc<sup>min/+</sup> intestinal polyps.
|
28414304 |
2017 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC-beta-catenin pathway are common in colon cancer.
|
10507776 |
1999 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations.
|
9196022 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Deletion analysis indicated that the N-terminal region of the APC protein mediated its junctional localisation, consistent with our observation that truncated APC proteins in colon cancer cell lines are still capable of localising to the cell cortex.
|
16423286 |
2006 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer.
|
21532750 |
2011 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.
|
23320800 |
2013 |
|
Malignant tumor of colon
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer.
|
11751382 |
2001 |
|
Malignant tumor of colon
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Expression of p16(INK4A) and APC genes is regulated by DNA methylation in three human colon cancer cell lines.
|
12970888 |
2003 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, transient transfection of an APC segment encoding amino acids 2140-2421 into a colon cancer cell line with mutant APC prevents cell cycle progression into or through S phase.
|
18474248 |
2008 |