APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE As most sporadic human colon tumors present adenomatous polyposis coli (APC) gene mutations, considerable effort has gone into developing mice that express mutant Apc alleles that mimic human colon cancer pathogenesis. 30859181 2019
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE Using NGS, the following mutations were detected: nonsense mutations in four tumor suppressor genes [APC R1114X (molecular argument that the cancer was a primary tumor of colon), TP53 R213X, RB1 E137X and FBWX7 R393X & S282X], mutations in three receptor tyrosine kinases (RET A919V of high transforming activity, EGFR E114K and FLT3 L601I) well known as oncogenes. 28730258 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE We investigated the presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated with any other genetic variants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient. 27816598 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer. 28576136 2017
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE Whereas some patients showed a single epigenotype in all tumors throughout the colon, tumors with two distinct epigenotypes developed within a family with the same APC mutation or even within one patient. 27563825 2016
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE We implemented the assay in four cell models: 1) a comparison of proliferating versus epidermal growth factor-stimulated A431 cells, 2) a comparison of SW480Null (mutant APC) and SW480APC (APC restored) colon tumor cell lines, and 3) a comparison of 10 colorectal cancer cell lines with different genomic abnormalities, and 4) lung cancer cell lines with either susceptibility (11-18) or acquired resistance (11-18R) to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib. 26631510 2016
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group CTD_human Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis. 26335331 2015
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 AlteredExpression group BEFREE In female APC(Min/+) mice, both dose levels of Frondanol A5 suppressed colon tumor multiplicities up to 80% (P < 0.0001). 25657017 2015
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE Deletion of Dnmt3a in APC((Min/+)) mice reduced colon tumor numbers by ~40%. 24837369 2015
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group CTD_human The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834 2014
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE Our findings show that 150 ppm OSU-HDAC42 significantly inhibited small-intestinal polyps (>46%; P < 0.001), with polyp size measuring >1 mm (P < 0.001), and colon tumors (>26%) in APC(min/+)mice, whereas 300 ppm SAHA showed nonsignificant inhibition. 24218540 2014
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group RGD Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. 19694754 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE Guanine deletions at this site in the Apc gene have been found to be preferentially induced by PhIP in rat colon tumors. 19628463 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE APC(Min) mice fed sucrose had an increased tumor number in the proximal third of the small intestine in both studies and a higher incidence of papillary colon tumors in the 16-wk feeding study (P < or = 0.05). 19116878 2009
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE We reliably detected germline SNPs and discovered a colon tumor specific nonsense mutation in APC, a gene causally implicated in colorectal cancer. 18849522 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group CTD_human Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. 17192441 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 AlteredExpression group LHGDN Truncated APC is required for cell proliferation and DNA replication. 16450383 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group LHGDN Examination of actin and microtubule dependent APC localisations in living mammalian cells. 16423286 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE The majority of colon tumors develop because of mutations in the tumor suppressor APC that lead to Wnt/beta-catenin signaling activation and subsequent transcription of target genes, including conductin/AXIN2. 16815967 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE Relatively high folate consumption reduced the risk of APC(-) colon tumors, but folate intake was positively associated with APC(+) colon tumors among men. 17116713 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE Although it is weaker than that in Apc gene-deficient mice, it may be linked to colon tumor development. 16478792 2006
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors. 15733272 2005
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 AlteredExpression group LHGDN Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. 15548520 2005
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 GeneticVariation group BEFREE Total meat consumption was not associated with the endpoints studied.Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). 16184469 2005
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.600 Biomarker group BEFREE The different pathways observed and their distribution can be summarized as follows: (a) K-ras mutations were more commonly detected in colon than in rectum; (b) the number of mutations detected was significantly higher in colon than in rectal tumors; and (c) a mutational pattern restricted to the APC gene was more common in rectal than in colon tumors. 15217933 2004