Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
As most sporadic human colon tumors present adenomatous polyposis coli (APC) gene mutations, considerable effort has gone into developing mice that express mutant Apc alleles that mimic human colon cancer pathogenesis.
|
30859181 |
2019 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Using NGS, the following mutations were detected: nonsense mutations in four tumor suppressor genes [APC R1114X (molecular argument that the cancer was a primary tumor of colon), TP53 R213X, RB1 E137X and FBWX7 R393X & S282X], mutations in three receptor tyrosine kinases (RET A919V of high transforming activity, EGFR E114K and FLT3 L601I) well known as oncogenes.
|
28730258 |
2017 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We investigated the presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated with any other genetic variants; we performed deep sequence analysis of APC in at least 2 adenomas or carcinomas per patient.
|
27816598 |
2017 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.
|
28576136 |
2017 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Whereas some patients showed a single epigenotype in all tumors throughout the colon, tumors with two distinct epigenotypes developed within a family with the same APC mutation or even within one patient.
|
27563825 |
2016 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
We implemented the assay in four cell models: 1) a comparison of proliferating versus epidermal growth factor-stimulated A431 cells, 2) a comparison of SW480Null (mutant APC) and SW480APC (APC restored) colon tumor cell lines, and 3) a comparison of 10 colorectal cancer cell lines with different genomic abnormalities, and 4) lung cancer cell lines with either susceptibility (11-18) or acquired resistance (11-18R) to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib.
|
26631510 |
2016 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
|
26335331 |
2015 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In female APC(Min/+) mice, both dose levels of Frondanol A5 suppressed colon tumor multiplicities up to 80% (P < 0.0001).
|
25657017 |
2015 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Deletion of Dnmt3a in APC((Min/+)) mice reduced colon tumor numbers by ~40%.
|
24837369 |
2015 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.
|
25200834 |
2014 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our findings show that 150 ppm OSU-HDAC42 significantly inhibited small-intestinal polyps (>46%; P < 0.001), with polyp size measuring >1 mm (P < 0.001), and colon tumors (>26%) in APC(min/+)mice, whereas 300 ppm SAHA showed nonsignificant inhibition.
|
24218540 |
2014 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
RGD |
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat.
|
19694754 |
2009 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Guanine deletions at this site in the Apc gene have been found to be preferentially induced by PhIP in rat colon tumors.
|
19628463 |
2009 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
APC(Min) mice fed sucrose had an increased tumor number in the proximal third of the small intestine in both studies and a higher incidence of papillary colon tumors in the 16-wk feeding study (P < or = 0.05).
|
19116878 |
2009 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We reliably detected germline SNPs and discovered a colon tumor specific nonsense mutation in APC, a gene causally implicated in colorectal cancer.
|
18849522 |
2008 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes.
|
17192441 |
2007 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Truncated APC is required for cell proliferation and DNA replication.
|
16450383 |
2006 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Examination of actin and microtubule dependent APC localisations in living mammalian cells.
|
16423286 |
2006 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The majority of colon tumors develop because of mutations in the tumor suppressor APC that lead to Wnt/beta-catenin signaling activation and subsequent transcription of target genes, including conductin/AXIN2.
|
16815967 |
2006 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Relatively high folate consumption reduced the risk of APC(-) colon tumors, but folate intake was positively associated with APC(+) colon tumors among men.
|
17116713 |
2006 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Although it is weaker than that in Apc gene-deficient mice, it may be linked to colon tumor development.
|
16478792 |
2006 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
|
15733272 |
2005 |
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
|
15548520 |
2005 |
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Total meat consumption was not associated with the endpoints studied.Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively).
|
16184469 |
2005 |
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
The different pathways observed and their distribution can be summarized as follows: (a) K-ras mutations were more commonly detected in colon than in rectum; (b) the number of mutations detected was significantly higher in colon than in rectal tumors; and (c) a mutational pattern restricted to the APC gene was more common in rectal than in colon tumors.
|
15217933 |
2004 |