APC, APC regulator of WNT signaling pathway, 324

N. diseases: 95; N. variants: 596
Disease: Colorectal Carcinoma ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 21531761 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. 21967605 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. 21291235 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human Methylation in the APC promoter may serve as a predictor for the prognosis of Taiwanese CRC patients. 19309276 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human WNT signaling pathway dysregulation is an important event in the pathogenesis of colorectal cancer (CRC) with APC mutations seen in more than 80% of sporadic CRC. 18716850 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human Although relatively high folate intake was not associated with overall colorectal cancer risk, it reduced the risk of APC(-)colon tumors in men (RR 0.58, 95% CI 0.32-1.05, P(trend) = 0.06 for the highest vs. lowest tertile of folate intake). 17116713 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease CTD_human Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. 12907644 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.800 GeneticVariation disease UNIPROT