Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
To further investigate the role of Wntless in tumorigenesis, APC-deficient spontaneous intestinal tumors and chemical induced colorectal cancer mouse models were employed.
|
31547988 |
2019 |
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Surprisingly, the targeted deletion of Jag1 but not RBPJ in LGR5<sup>+ve</sup> tumor-initiating cells resulted in the silencing of Hes1 expression, disruption of the tumor stem cell niche, and dramatic reduction in the proliferation activity of APC-deficient intestinal tumors in vivo.
|
27939883 |
2017 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In vivo, valproate diminished (65%) the number of intestinal tumors in APC mutant mice, slowed down xenograft tumor growth concomitant to restored CXCL12 expression.
|
28418886 |
2017 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Gene Expression Profile of Colon Mucosa after Cytotoxic Insult in wt and Apc-Mutated Pirc Rats: Possible Relation to Resistance to Apoptosis during Carcinogenesis.
|
27840820 |
2016 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
|
26335331 |
2015 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
APC(Min/+) mice were fed semi-purified diets containing 0, 250, or 500 ppm FrondanolA5 for 14 weeks before we assessed intestinal tumor inhibition.
|
25657017 |
2015 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Here, we describe our current laboratory protocols to generate and analyze intestinal tumors and organoids harboring APC and K-Ras double mutations.
|
25636467 |
2015 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, a single copy deletion of CXCR2 gene resulted in abrogation of COX-2 and Gro-α upregulation in intestinal tumors caused by the APC mutation.
|
24338666 |
2014 |
Intestinal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells.
|
23393221 |
2013 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We show here that ZEB1 is expressed by epithelial cells in intestinal tumors from human patients (familial adenomatous polyposis) and mouse models (APC(Min/+)) with germline mutations of APC that result in nuclear accumulation of β-catenin.
|
22080605 |
2011 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Six-week-old male and female APC(Min/+) mice (n = 10 per group) were fed with control American Institute of Nutrition-76A diet or diets containing 150 or 300 ppm licofelone for 14 weeks (∼100 days), and intestinal tumors were evaluated for tumor multiplicity and size.
|
21885812 |
2011 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Enigmol also had antitumor efficacy when administered orally to Min mice, a mouse model with a truncated APC gene product (C57Bl/6J(Min/+) mice), decreasing the number of intestinal tumors by half at 0.025% of the diet (w/w), with no evidence of host toxicity until higher dosages.
|
21398423 |
2011 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Crypt stem cells as the cells-of-origin of intestinal cancer.
|
19092804 |
2009 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors.
|
19578404 |
2009 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice.
|
16962818 |
2006 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice.
|
14706516 |
2004 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Upregulation of conductin was also observed in the APC-deficient intestinal tumors of Min mice.
|
11809809 |
2002 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Min mice are heterozygous for a nonsense mutation in the murine adenomatous polyposis coli (APC) gene and spontaneously develop multiple intestinal neoplasms similar to the familial adenomatous polyposis (FAP) syndrome in humans.
|
10868458 |
2000 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the multiple intestinal neoplasia (Min) gene, the mouse homologue of the APC gene, result in the development of intestinal tumors.
|
9527272 |
1998 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice.
|
9111214 |
1997 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Apc1638N mouse carries a targeted mutant allele at the endogenous adenomatous polyposis coli (Apc) gene and represents a unique in vivo model to study intestinal tumor formation and progression.
|
9054624 |
1997 |
Intestinal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Similar loss of APC was not associated with the development of other extra-intestinal tumors.
|
7478622 |
1995 |
Intestinal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline mutations of the adenomatous polyposis coli (APC) gene lead to multiple intestinal tumors in familial adenomatous polyposis patients and in multiple intestinal neoplasia (Min) mice.
|
7954428 |
1994 |