APC, APC regulator of WNT signaling pathway, 324

N. diseases: 95; N. variants: 596
Disease: Intestinal Polyps ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.490 Biomarker phenotype CTD_human As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. 14991580 2004
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.490 Biomarker phenotype CTD_human When Apc gene knockout mice (APC1309 mice) were given 600 or 1200 p.p.m. mofezolac in their diet for 8 weeks, the numbers of intestinal polyps were also dose-dependently decreased, with reduction to 59% of that in the control diet group at the higher dose. 12189188 2002
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.490 Biomarker phenotype CTD_human Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in Apc delta 716 knockout mice. 8561861 1996