|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated human colon cancers and Apc<sup>min/+</sup> intestinal polyps.
|
28414304 |
2017 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Here we applied whole-genome sequencing (WGS) to the DNA of a sporadic FAP patient in which we did not find any pathological APC mutations by direct sequencing.
|
27217144 |
2016 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
We give evidence that this extracolonic manifestation of FAP is determined by the same germline mutation of the APC gene responsible for colonic polyps and cancer but also shows some unusual features (F : M ratio = 80 : 1, absence of LOH for APC in the thyroid tumoral tissue, and indolent biological behaviour, despite frequent multicentricity and lymph nodal involvement), suggesting that the APC gene confers only a generic susceptibility to thyroid cancer, but perhaps other factors, namely, modifier genes, sex-related factors, or environmental factors, are also required for its phenotypic expression.
|
26697262 |
2015 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.
|
25280562 |
2014 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.
|
25200834 |
2014 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.
|
23788249 |
2013 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene.
|
21643010 |
2011 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
We could not detect any somatic mutations in tumor C. We conclude that somatic mutation analysis of the APC gene can be used to identify whether a recurrent desmoid tumor in a patient with FAP is a new primary tumor or a recurrence from microscopic remnants of the original tumor.
|
18704758 |
2009 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
|
17942926 |
2007 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case.
|
12394442 |
2002 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Attenuated familial adenomatous polyposis associated with advanced rectal cancer in a 16-year-old boy: report of a case.
|
11766074 |
2001 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele.
|
11420398 |
2001 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis.
|
11588890 |
2001 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
[Familial adenomatous colonic polyposis].
|
11040535 |
2000 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
We have found that FAP patients with germline APC mutations within a small region (codons 1,194-1,392 at most) mainly show allelic loss in their colorectal adenomas, in contrast to other FAP patients, whose 'second hits' tend to occur by truncating mutations in the mutation cluster region.
|
10470088 |
1999 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
We screened the entire coding region of the APC gene for mutations in an unselected series of 105 Dutch FAP kindreds.
|
8990002 |
1997 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Germ-line mutations in the adenomatous polyposis coli (APC) gene characteristic of familial adenomatous polyposis were evaluated, as well as DNA replication errors and germline mutations in nucleotide mismatch-repair genes characteristic of hereditary nonpolyposis colorectal cancer.
|
7661930 |
1995 |
|
Adenomatous Polyposis Coli
|
1.000 |
Biomarker
|
disease |
CTD_human |
Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.
|
8071957 |
1994 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
We examined the first 14 exons of the APC gene in 46 polyposis coli patients.
|
7833149 |
1994 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients.
|
7833931 |
1994 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Our results provide information helpful to an understanding of the APC gene and will also contribute to presymptomatic diagnosis of members in FAP families.
|
1338764 |
1992 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients.
|
1338904 |
1992 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.
|
1338691 |
1992 |
|
Adenomatous Polyposis Coli
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
These data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
|
1651563 |
1991 |