Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin (Hp) 2-2 genotype has been shown to increase the risk of coronary artery disease, kidney dysfunction and mortality from cardiovascular and renal causes in type 1 diabetes (T1D).
|
31529337 |
2020 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Haptoglobin Phenotype Is Associated With High-Density Lipoprotein-Bound Hemoglobin Content and Coronary Endothelial Dysfunction in Patients With Mild Nonobstructive Coronary Artery Disease.
|
30727751 |
2019 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging.
|
29896420 |
2018 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haptoglobin 2-2 genotype and the risk of coronary artery disease in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC).
|
27539884 |
2018 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It associates with lower levels of haptoglobin (P = 2.1 × 10-54), higher levels of non-high density lipoprotein cholesterol (β = 0.26 mmol/l, P = 2.6 × 10-9) and greater risk of coronary artery disease (odds ratio = 1.30, 95% confidence interval: 1.10-1.54, P = 0.0024).
|
28398513 |
2017 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haptoglobin polymorphism in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and near-infrared spectroscopy in patients with coronary artery disease.
|
27423090 |
2016 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that, although better control may reduce the incidence of coronary artery disease in Type 1 diabetes, a residual risk related to the haptoglobin 2 allele remains.
|
27028131 |
2016 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary Artery Disease.
|
27353603 |
2016 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The haptoglobin (Hp) 2 allele directly predicts coronary artery disease in type 1 diabetes, potentially due to its decreased antioxidative/anti-inflammatory properties.
|
26114833 |
2015 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HbA1c concentration and Hp genotype were determined for 695 incident cases of CHD from 1994 to 2010 and matched control participants.
|
26483103 |
2015 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between haptoglobin 2-2 genotype and coronary artery disease and its severity in a tunisian population.
|
24535155 |
2014 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We prospectively evaluated the haptoglobin (Hp)-stroke association in type 1 diabetes and hypothesized that despite increasing the risk of coronary artery disease, the presence of the Hp 2 allele would be associated with a lower incidence of stroke.
|
24994788 |
2014 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HbA(1c) concentration and Hp genotype were determined for 407 CHD cases matched 1:1 to controls (from the NHS [Nurses' Health Study]) and in a replication cohort of 2,070 individuals who served as the nontreatment group in the ICARE (Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment) study, with 29 CHD events during follow-up.
|
23312704 |
2013 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin.
|
22098782 |
2011 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Haptoglobin (Hp) 2-2 phenotype has been associated with peripheral and coronary artery disease and risk of vascular complications in diabetic patients, but any association of Hp polymorphism with cerebrovascular disease has not been explored so far.
|
18691072 |
2008 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The possible association of allelic polymorphism of haptoglobin with various pathologic conditions such as coronary artery disease has been studied.
|
15298155 |
2004 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data are consistent with an interaction between Hp type and diabetes in the prevalence of CHD.
|
15019547 |
2004 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
in contrast to the findings from cross-sectionally based studies, the results from this longitudinal study show that Hp 1-1 individuals are at elevated risk for CHD mortality.
|
11427216 |
2001 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, haptoglobin polymorphism may play an important role in the regulation of lipoprotein metabolism and could contribute to the risk of coronary heart disease.
|
10217368 |
1999 |
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study thus indicated that genetic variation of APOB, LPL, CETP, and lecithin cholesterol acyl transferase (which is linked to HPA and CETP) may play an important role in the regulation of lipoprotein metabolism and could contribute to the risk of coronary artery disease.
|
8279486 |
1993 |