|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Patients with c-Ha-ras p21-positive carcinomas had a significantly worse prognosis than those with p21-negative carcinomas.
|
3089984 |
1986 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Acquired mutations of the c-k-ras gene are commonly found in colonic adenomas and carcinomas.
|
8471756 |
1993 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
C-myc and c-Ha-ras oncoprotein expression was studied by immunohistochemistry and gene detection by in situ hybridization on serial frozen sections of 32 breast lesions (19 benign biopsies and 13 infiltrating carcinomas).
|
8003818 |
1994 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Our method of topographic genotyping of human colonic carcinomas has shown a correlation between K-ras-2 and p53 mutations and stage at diagnosis as well as long-term survival.
|
9142390 |
1997 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutant c-K-ras genes were detected in about 75% of adenocarcinomas of the pancreas (n = 84); 40% of adenomas (n = 72) and carcinomas (n = 244) of the colon end rectum; 30% of carcinomas of the bile duct (n = 19); 25% of carcinomas of the lung (n = 92), and in lower frequency in other carcinomas, including liver, stomach, and kidney.
|
1685441 |
1991 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Thirty per cent of the carcinomas exhibited heterogeneous staining stronger than that of normal breast, interpreted as increased expression of p21ras protein.
|
3058913 |
1988 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Screening of human bladder carcinomas for the presence of Ha-ras codon 12 mutation.
|
10767358 |
2000 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
HRAS mutations accounted for more than 90% of RAS mutations, occurring especially in epithelial-myoepithelial carcinomas and salivary duct carcinomas.
|
26053092 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Paradoxically, reports have suggested a greater frequency of Ki-ras gene mutation in these lesions than in more complex lesions such as benign colonic adenomas and carcinomas.
|
21443421 |
2011 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
On the other hand, Ki-ras gene mutations were inversely correlated with MSI, which was found in diploid carcinomas only.
|
11754204 |
2001 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The ELISA is a feasible and valid approach for identifying p21ras mutations in human colorectal adenomas and carcinomas.
|
8625092 |
1995 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
None of the gastric and seven of the colorectal tumors had mutations of the c-K-ras gene. p53 gene mutations were detected in six gastric carcinomas [two out of 11 intramucosal carcinomas (18.2%) and four out of 11 invasive carcinomas (36.4%)].
|
7665812 |
1995 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Using a transgenic mouse model expressing the E2F1 gene under the control of a keratin 5 (K5) promoter, we previously demonstrated that increased E2F1 activity can promote tumorigenesis by cooperating with either a v-Ha-ras transgene to induce benign skin papillomas or p53 deficiency to induce spontaneous skin carcinomas.
|
10454586 |
1999 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore it is of interest to investigate whether expression of human c-Ha-ras affects the androgen-dependence of prostate carcinomas developing in the PB/SV40T Tg rat.
|
14662018 |
2003 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas.
|
25795707 |
2015 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The mutational frequency of the Ki-ras gene in the present series of small intestinal carcinomas was similar, while that of the p53 gene was slightly lower than the reported frequencies for colorectal carcinomas.
|
9033644 |
1997 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations of K-RAS-2 gene and tumour suppressor genes have been found in both colorectal adenomas and carcinomas.
|
9361177 |
1997 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Enhanced Ha-ras expression was documented in 66% of breast and 100% of colon carcinomas as compared with their normal counterparts, with levels in breast carcinomas ranging from 10.1 to 50.4 pg ras p21/micrograms protein and those in colon carcinomas ranging from 18.4 to 51.7 pg ras p21/micrograms protein.
|
3298786 |
1987 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Combined Harvey rat sarcoma viral oncogene homolog/phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit α (HRAS/PIK3CA) mutations were observed predominantly in de novo carcinomas (5 of 8 vs 2 of 31 tumors; P = .035).
|
27379604 |
2016 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These results demonstrate that, not only is the timing and frequency of C-KI-RAS activation different between carcinomas originating on the left or right of the colorectum, but also that the biological consequences of such mutations may differ.
|
8814697 |
1996 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Using in vitro gene amplification by the polymerase chain reaction (PCR) and mutation detection by the RNAase A mismatch cleavage method, we have examined c-K-ras genes in human pancreatic carcinomas.
|
2453289 |
1988 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The findings for the Ki-ras gene in 42 paired carcinomas and synchronous metastases were identical, regardless of whether or not the carcinoma and its companion adenoma had identical Ki-ras findings.
|
12782759 |
2003 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Detection of human papillomavirus genome and analysis of expression of c-myc and Ha-ras oncogenes in invasive cervical carcinomas.
|
1326470 |
1992 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Higher frequency of point mutations in the c-K-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas.
|
1708754 |
1991 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Given the advantages of rat models characterized by larger organ size, abundant information regarding preneoplasias and virus-free constitution, we have concentrated on the generation of transgenic rats bearing copies of the human c-Ha-ras proto-oncogene and shown the Hras128 strain to be extremely sensitive to the induction of mammary carcinomas, and to a lesser extent, lesions in the urinary bladder, esophagus and skin.
|
15958052 |
2005 |