|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
RNA sequencing and Sanger sequencing identified PIK3CA (p.E545K/p.H1047R) and/or HRAS (p.Q61R) hotspot mutations in 6 of 8 (75%) apocrine carcinomas.
|
29443014 |
2018 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We found that overexpression of either transfected normal or mutated HRAS genes converted RT-4 cells to express an invasive phenotype remarkably similar in nature to the clinical behavior of high-grade bladder carcinomas.
|
2247480 |
1990 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results thus indicate that the loss of one H-ras-1 allele correlates with the most aggressive primary carcinomas of the breast.
|
3524819 |
1986 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Proteins encoded by cellular ras oncogenes (p21ras) are expressed in a wide variety of malignant tumors, including carcinomas, lymphomas, and neuroectodermal tumors.
|
3554234 |
1987 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
RAS mutations in codon 61 were by far the most common genetic alteration in poorly differentiated carcinomas (23% of cases), with all mutation in NRAS except one in the HRAS gene.
|
19837916 |
2009 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
K14/IL-1 alpha mice crossed with the highly sensitive TG.AC mice, constitutively expressing mutant Ha-Ras, also failed to develop papillomas or carcinomas.
|
12759452 |
2003 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The farnesyltransferase inhibitor L-744,832 selectively blocks the transformed phenotype of cultured cells expressing a mutated H-ras gene and induces dramatic regression of mammary and salivary carcinomas in mouse mammary tumor virus (MMTV)-v-Ha-ras transgenic mice.
|
9418856 |
1998 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The authors propose that the expression of Ha-ras p21 may be one of the useful prognostic factors in such carcinomas.
|
1310887 |
1992 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis.
|
1854618 |
1991 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
KRAS2 mutations were seen in 5/51 (10%) MSI-positive carcinomas.
|
11746970 |
2001 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras, in primary human carcinomas and the adjacent analogous normal tissues from which the tumors derived.
|
6187346 |
1983 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among 74 KRAS2-mutant carcinomas, no BRAF mutations were identified.
|
14507635 |
2003 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Activating point mutations of genes of the RAS family (KRAS, HRAS and NRAS genes) are frequently found in carcinomas, but their prevalence in sarcomas varies considerably among ethnic groups.
|
20150643 |
2010 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In contrast, no point mutation was detected in the 12th, 13th, and 61st codon of the c-Ki-ras and c-Ha-ras gene in 31 primary esophageal carcinomas including those from which TE1 and TE2 cell lines were established.
|
1520342 |
1992 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Analysis of HK1.fos/alpha papillomas and carcinomas revealed that the endogenous c-Ha-ras gene possessed mutations at codons 12, 13, and 61 at the papilloma stage, but no mutations of the p53 tumor suppressor gene were detected.
|
10569807 |
1999 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The absence of ras mutations in the epithelium of primary oral squamous-cell carcinomas is of considerable interest as other work in our Department on Indian cases of oral carcinomas associated with chewing tobacco (quid) revealed that 35% of these had a codon 12, 13 or 61 mutation in Ha-ras.
|
2040536 |
1991 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin.
|
23380875 |
2013 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results are the first demonstration of Ha-ras intron D alterations in human tumor tissues and suggest that concurrent mutations at codon 12 and intron D of this gene within the same tumor may contribute to the aggressive behavior of human bladder carcinomas.
|
1427748 |
1992 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results obtained on a large series confirm the frequent occurrence of Ha-ras codon 12 gene mutations both in adenomas and in carcinomas.
|
9724079 |
1998 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We have previously demonstrated that transfection and overexpression of normal or mutated c-Ha-ras genes into a noninvasive human papillary transitional cell carcinoma cell line confer upon these cells an invasive phenotype in vivo with behavior remarkably similar to the clinical behavior of high grade bladder carcinomas.
|
1868471 |
1991 |
|
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that erB-2 and Ha-ras co-expression can induce a more aggressive phenotype in vitro, representative of the malignancy of mammary carcinomas.
|
8847140 |
1995 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Importantly, these studies also suggest for the first time that the distinct and likely cooperative biological functions of the Ki-ras-encoded Ki-Ras 4A and Ki-Ras 4B proteins may help explain why constitutively activating mutations of Ki-ras, but not N-ras or Ha-ras, are frequently detected in human carcinomas.
|
10358073 |
1999 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Different genes, located as the c-Ha-ras gene on the short arm of chromosome 11, were also found to be deleted suggesting that the deletion of other genes could play a role in aggressiveness of head and neck carcinomas.
|
1698442 |
1990 |
|
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To determine whether atypical epithelium may be precancerous, we examined the DNA sequence of the c-Ki-ras gene at codon 12 in nine cases of CBD concurrent with seven gallbladder carcinomas, one bile duct carcinoma, and one bile duct atypical epithelium.
|
8651173 |
1996 |
|
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
If a mutation of c-K-ras 2 gene is an important component in the formation of adenocarcinoma, these results did not confirm the successive development from adenomas with severe atypia to advanced carcinomas as the main route for colorectal carcinogenesis in familial adenomatous polyposis patients.
|
1333425 |
1992 |