Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
BEFREE |
HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer.
|
29901113 |
2018 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that mosaicism for oncogenic HRAS mutations may increase the risk for developing BC at a young age.
|
24169525 |
2014 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is evident from our study that HRAS T81C SNP moderately increases bladder cancer risk, and rare allele is a predictive marker of advanced bladder tumors.
|
21514184 |
2013 |
Malignant neoplasm of urinary bladder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Analysis of HRAS gene TRR methylation showed that the methylation level of HRAS has clinical relevance (P = 0.0049, by unpaired Student's t test) with bladder cancer.
|
22707223 |
2012 |
Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
BEFREE |
HRAS is a proto-oncogene involved in the tumorigenesis of urinary bladder cancer.
|
21931711 |
2011 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer.
|
16338065 |
2006 |
Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
CTD_human |
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
|
15958052 |
2005 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HRAS1 genotype may be related to the prognosis of bladder cancer, however, because incident cases, i.e., newly diagnosed cases had a higher frequency of rare alleles than did prevalent cases, i.e., cases already existing at the time of recruitment.
|
12115522 |
2002 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the bladder cancer cell lines were subjected to sequence analysis to identify a point mutation in the c-H-ras gene at codon 12.
|
10995035 |
2000 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The c-Ha-ras-1 locus was studied by Southern blotting in white blood cells and tumor samples obtained from 126 patients with bladder cancer (74 Ta-T1 and 52 T2-T4).
|
8583569 |
1996 |
Malignant neoplasm of urinary bladder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Lack of influence of c-Ha-ras expression on the drug sensitivity of human bladder cancer histocultured in three-dimensions.
|
8352563 |
1993 |
Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
CTD_human |
Activating missense mutations in Ha-ras-1 genes in a malignant subset of bladder lesions induced by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-[4-(5-nitro-2-furanyl)-2-thiazolyl]formamide.
|
2278634 |
1990 |
Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
CTD_human |
Oncogene expression of FANFT- or BBN-induced rat urothelial cells.
|
2228319 |
1990 |
Malignant neoplasm of urinary bladder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Malignant properties of sublines selected from a human bladder cancer cell line that contains an activated c-Ha-ras oncogene.
|
3409229 |
1988 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma.
|
2892780 |
1988 |
Malignant neoplasm of urinary bladder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, deletion of one Ha-ras allele was observed in 1 of 5 cases of bladder cancer and in 2 of 3 cases of renal pelvic cancer, suggesting that that deletion may be important in the development of urothelial cancer.
|
2889677 |
1987 |
Malignant neoplasm of urinary bladder
|
0.700 |
Biomarker
|
disease |
BEFREE |
A point mutation alters the 12th amino acid of the c-Ha-ras oncogene product p21 in a human bladder cancer cell line.
|
6304875 |
1983 |
Malignant neoplasm of urinary bladder
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of urinary bladder
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|