Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Both cell subsets rapidly progressed to cancer upon introduction of constitutively active versions of either HRAS or BRAF.
|
30401712 |
2019 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
|
30787043 |
2019 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The co-delivery of anti-p21Ras scFv by CIK cells and KGHV500 could increase the anti-tumor effect and safety, and possess considerable advantages for the treatment of Ras-related cancer.
|
30796510 |
2019 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Due to ubiquitous HRAS gene expression, CS affects multiple organ systems and individuals are predisposed to cancer.
|
31222966 |
2019 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Preoperative RAS mutation detection in thyroid nodules carries a substantial risk of cancer with a greater risk associated with HRAS and NRAS.
|
27863786 |
2017 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although some individuals with HRAS p.Gly13Asp developed papillomata and vascular proliferation lesions, no malignant tumors occurred, similar to what was reported for individuals harboring the HRAS p.Gly13Cys.
|
28371260 |
2017 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53.
|
28799801 |
2017 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Ras mutations and overexpression of the Ras protein, p21Ras, are main causes of cancer development and progression, which has made the Ras gene and p21Ras important targets for therapy of Ras-driven cancers.
|
27834948 |
2017 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results indicate that the adenovirus-mediated intracellular expression of the novel anti-p21Ras scFv exerted strong antitumoral effects, and may be a potential method for therapy of cancers with p21Ras overexpression.
|
26780944 |
2016 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Somatic KRAS and HRAS mutations occur with comparable frequency in isolated malignancies.
|
26572961 |
2016 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer.
|
27195699 |
2016 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results show that HRAS mutations in cancer activate the RAS and mTOR pathways which might serve as a therapeutic option for patients with HRAS mutant tumors.
|
26544513 |
2015 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The small GTPase KRAS is frequently mutated in human cancer and currently there are no targeted therapies for KRAS mutant tumors.
|
25805818 |
2015 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
HRAS is a proto-oncogene and has potential to cause cancer in several organs including the bladder.
|
27352265 |
2015 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These data suggest that farnesyl transferase inhibitors should be reevaluated as targeted agents for human HRAS-driven cancers, such as those of bladder, thyroid and other epithelial lineages.
|
24240680 |
2014 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Oncogenic HRAS in HNSCC promotes activation of ERK signaling, which in turn mediates cetuximab resistance through a specific gene expression signature.Clin Cancer Res; 20(11); 2933-46.©2014 AACR.
|
24696319 |
2014 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although somatic HRAS mutations have been described in many cancers, germline mutations cause Costello syndrome (CS), a congenital disorder associated with predisposition to malignancy.
|
24259709 |
2013 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Specific acquired HRAS mutations have been found to predominate in bladder cancer, and HRAS T81C polymorphism has been determined to contribute the risk of various cancers, including bladder cancer.
|
21514184 |
2013 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Specific acquired RAS mutations have been found to predominate in different cancers, and HRAS T81C polymorphism has been determined to contribute the risk of various cancers, including thyroid cancer.
|
23150177 |
2013 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Abnormal methylation of the HRAS gene may be an early event during urocystic tumorigenesis and may be further used as a cancer biomarker in bladder tissue for early diagnosis and a potential therapeutic target.
|
22707223 |
2012 |
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Two miRNA candidates known to be downregulated in the majority of pancreatic cancers were selected for nanovector delivery: miR-34a, which is a component of the p53 transcriptional network and regulates cancer stem cell survival, and the miR-143/145 cluster, which together repress the expression of KRAS2 and its downstream effector Ras-responsive element binding protein-1 (RREB1).
|
21622730 |
2011 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, and HRAS), our analysis revealed many genes not previously implicated in this malignancy.
|
21798893 |
2011 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Over the last century, the history of cancer epidemiology evolved in different stages and concepts from occupational observational studies beginning in the 18th century, in vitro and in vivo experimental analyses and cancer gene analyses, such as Ha-ras or TP53.
|
21791238 |
2011 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.
|
21931711 |
2011 |
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we aimed to characterize common and unique miRNAs regulated by transcriptional regulators such as oncogenic HRAS, c-Jun and E2F family members (E2F1≈E2F6) in the human cancer cell lines A549 and HeLa.
|
20878133 |
2010 |