|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Mutations that activate the small GTPase KRAS are found in 20% to 30% of NSCLCs.
|
24292713 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Functional specificity of ras isoforms: so similar but so different.
|
21779495 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The combined HR was 1.35 (95% CI: 1.16-1.56), showing a worse survival for NSCLC with KRAS2 mutations or p21 overexpression and, particularly, in adenocarcinomas (ADC) (HR 1.59; 95% CI 1.26-2.02) and in studies using PCR (HR 1.40; 95% CI 1.18-1.65) but not in studies using IHC (HR 1.08; 95% CI 0.86-1.34).
|
15597105 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
These results showed that the majority of the primary NSCLCs with Kras2 mutations lack RASSF1A inactivation, and both RASSF1A inactivation and Kras2 mutation events occur frequently in adenocarcinomas and large cell carcinomas.
|
14511407 |
2004 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.
|
12606951 |
2003 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Role of the switch II region in the conformational transition of activation of Ha-ras-p21.
|
10716188 |
2000 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
Biomarker
|
disease |
BEFREE |
Alterations in 5 microsatellite loci were analyzed in tumors from 137 patients with primary non-small cell lung carcinomas that were also genotyped for the Hras1 variable number of tandem repeats (VNTR) locus.
|
7664270 |
1995 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
PosttranslationalModification
|
disease |
BEFREE |
We conclude that hypomethylation at specific sites in the 3' region is associated with loss of heterozygosity for the c-Ha-ras gene in non-small cell lung cancer.
|
8118795 |
1994 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
Biomarker
|
disease |
BEFREE |
In our model, the insertion of the v-Ha-ras oncogene into c-myc overexpressing NCI-H82 small cell lung cancer cells induces features characteristic of non-small cell lung cancer.
|
8123593 |
1994 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
In addition, where transfection of SCLC cell lines with the v-Ha-ras protooncogene caused a transition to a NSCLC phenotype, DTD activity was also elevated.
|
1324793 |
1992 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
|
2674130 |
1989 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
The ras gene family and human carcinogenesis.
|
3283542 |
1988 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
ras genes.
|
3304147 |
1987 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells.
|
3004741 |
1986 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.
|
6288698 |
1982 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.
|
6287573 |
1982 |
|
Non-Small Cell Lung Carcinoma
|
0.180 |
GeneticVariation
|
disease |
CLINVAR |
Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.
|
6287572 |
1982 |