Liver neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
The similarity in the patterns of global gene expression of Ha-ras and B-raf mutated liver tumors suggests that mutational activation of the 2 oncogenes results in activation of a common set of transcriptional regulators.
|
17514646 |
2007 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
The incidence of KRAS2 mutations in human compared to mouse lung tumors differed significantly, as did the incidence of Hras and p53 gene mutations in human compared to mouse liver tumors.
|
16410370 |
2006 |
Liver neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
The incidence of KRAS2 mutations in human compared to mouse lung tumors differed significantly, as did the incidence of Hras and p53 gene mutations in human compared to mouse liver tumors.
|
16410370 |
2006 |
Liver neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Experimentally induced liver tumors in mice harbor activating mutations in either Catnb (beta-catenin) or Ha-ras, according to the carcinogenic treatment.
|
15965925 |
2005 |
Liver neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
The high prevalence of Ha-ras and B-raf mutations in mouse liver tumors is in striking contrast to human hepatocellular cancers which very infrequently harbor mutations in the two genes.
|
15592514 |
2005 |
Liver neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
The frequency of liver tumors and glucose-6-phosphatase-altered liver lesions was almost identical in all three P53 genotypes and approximately 40-50% of liver tumors showed activating mutations in codon 61 of the Ha-Ras gene independent of genotype.
|
15917304 |
2005 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
|
12082015 |
2002 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
|
12127263 |
2002 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene.
|
10874023 |
2000 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
These results indicate that spontaneous liver tumors in rasH2 Tg mice contain different mutation patterns depending on the histologic type or cell origin of the tumors (i.e., hepatocellular carcinomas or hepatic hemangiosacomas).
|
9715515 |
1998 |
Liver neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
No mouse c-Ha-ras gene mutations were detected in any of the 47 liver tumors examined, which had developed in Tg and N-Tg mice.
|
8766521 |
1996 |
Liver neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
Erb (B), erb (A+B), Ha-ras, myc, fos and fms oncogene expression elevated in certain stages of fetal liver development and in hepatoma as compared to the normal adult human liver.
|
3030308 |
1987 |