|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To define functional activities of mutant KRAS in a hypoxic microenvironment, we first performed cDNA microarray experiments in isogenic DKs5 and DKO3 colon cancer cell lines that differ only by their expression of mutant KRAS (K-ras(D13)).
|
24519534 |
2014 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The strongest association for the rs1205 polymorphism and colon cancer was observed among those with KRAS2 mutations (OR 1.5, 95%CI 1.1-2.0).
|
20949557 |
2011 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic instability may occur on 12p-12-13 of Kras2 gene in the development and progression of colon carcinoma.
|
16534842 |
2006 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that polymorphisms in some insulin-related genes are associated with an increased risk of colon cancer with specific KRAS2 and TP53 mutations, implying a link between these genetic changes and specific mutational pathways in carcinogenesis.
|
16448675 |
2006 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further evaluate sporadic colon carcinoma risk associated with rare HRAS1 VNTR alleles, the relationship with microsatellite instability and with HRAS1 VNTR instability.
|
11724366 |
2001 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results, together with our previous observations of a relative lack of Ki-ras gene mutations in the same tumors, are similar to those found in human UC-associated colon cancer, suggest a common pathway in these two systems, although they are different in their implication of p53 mutations.
|
9433483 |
1997 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linkage analysis shows that these susceptibility genes are different from the mouse homologs of the genes known to be somatically mutated in human colon cancer (KRAS2, TP53, DCC, MCC, APC, MSH2, and probably also MLH1).
|
8577718 |
1996 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon.
|
8554149 |
1996 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stable transfection of Ha-ras into the human colon cancer line CaCo2 results in the morphologic differentiation to a small bowel phenotype.
|
7769122 |
1995 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the Ki-ras gene is frequently mutated in human colon cancer, the Ha-ras protooncogene is maximally expressed in the most differentiated cells of intestinal mucosa.
|
8494794 |
1993 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The c-myc gene is amplified and the c-Ki-ras gene is mutated in the SW613-S human colon carcinoma cell line.
|
1399125 |
1992 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These combined results suggest that mutations in KRAS2 occur early in the development of human colon carcinoma, before change in ploidy, and that these mutations exist in diploid cells from which an aneuploid subpopulation arises.
|
2648401 |
1989 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic implications of expression of the cellular genes myc, fos, Ha-ras and Ki-ras in colon carcinoma.
|
3040597 |
1987 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This suggests that activation of the c-K-ras 2 oncogene could be associated with colon carcinoma induction.
|
3021699 |
1986 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using the NIH 3T3 transformation assay system, an activated c-Ha-ras transforming gene has been identified in three distinct early passage colon carcinoma cell lines isolated from an invasive, differentiated, adenocarcinoma.
|
2994902 |
1985 |