RAB37, RAB37, member RAS oncogene family, 326624

N. diseases: 32; N. variants: 15
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Rab37 has been postulated as a tumor suppressive small GTPase for trafficking anti-tumor cargos. 30158579 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Dysfunction of Rab37 or loss of TSP1 abrogated the suppressive effects on angiogenesis and metastasis.<b>Conclusions:</b> Our findings suggest that Rab37-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression. 28151721 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 PosttranslationalModification group BEFREE Therefore, we further examined the mRNA expression and promoter/exon1 hypermethylation of hRAB37 gene in paired normal and tumor lung tissue from 71 non-small cell lung cancer (NSCLC) patients. 18687502 2009