|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present findings may suggest a surprisingly high variability of the H2R gene polymorphisms in different geographical areas but do not support an association of these allelic variations with schizophrenia.
|
10822343 |
2000 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Individuals with schizophrenia have an increased incidence of the H2R649G allele for the histamine H2 receptor gene.
|
9154248 |
1996 |
|
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Drug-Induced Liver Disease
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.
|
22926047 |
2013 |
|
Coronary Stenosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Effects of different beta adrenoceptor ligands in mice with permanent occlusion of the left anterior descending coronary artery.
|
12721106 |
2003 |
|
Substance Withdrawal Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice.
|
8870037 |
1996 |
|
Drug Withdrawal Symptoms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice.
|
8870037 |
1996 |
|
Withdrawal Symptoms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice.
|
8870037 |
1996 |
|
Carcinoma, Transitional Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer.
|
6224980 |
1983 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
We report that the primary growth of this tumor in the footpad and its metastasis to lung are correlated with the development of increased numbers of suppressor cells, characterized by the expression of a surface histamine H2 receptor.
|
6224980 |
1983 |
|
Neoplasms, Experimental
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer.
|
6224980 |
1983 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Postischemic regulation of central histamine receptors.
|
16181737 |
2005 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The association of SNPs in HRH2 with incident HF was characterized using Cox proportional hazards regression among participants in the Multi-Ethnic Study of Atherosclerosis.
|
29191567 |
2018 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
The association of SNPs in HRH2 with incident HF was characterized using Cox proportional hazards regression among participants in the Multi-Ethnic Study of Atherosclerosis.
|
29191567 |
2018 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The T allele of rs3787429 exhibited protective effect against CHF under the dominant (ORs = 0.455; 95% CIs = 0.322-0.642) and additive models (ORs = 0.662; 95% CIs = 0.523-0.838), while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study.
|
26989676 |
2016 |
|
Colonic Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine.
|
18258331 |
2008 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To study the effect of granulocyte macrophage-colony-stimulating factor (GM-CSF) on histamine metabolism in arteriosclerosis, the expression of histidine decarboxylase (HDC; histamine-producing enzyme), histamine receptors 1 and 2 (HH1R and HH2R), and GM-CSF was investigated in human and mouse arteriosclerotic carotid arteries.
|
15514212 |
2005 |
|
Colonic Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
|
16203768 |
2005 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Greater ratios of gene expression of H2R ( HRH2) vs. H1R ( HRH1) were correlated with improved overall survival outcomes in patients with colorectal cancer.
|
30462522 |
2019 |
|
Laryngopharyngeal Reflux
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR.
|
30643081 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Greater ratios of gene expression of H2R ( HRH2) vs. H1R ( HRH1) were correlated with improved overall survival outcomes in patients with colorectal cancer.
|
30462522 |
2019 |