HES1, hes family bHLH transcription factor 1, 3280

N. diseases: 243; N. variants: 0
Disease: Medulloblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.050 Biomarker disease BEFREE HES1 was identified as a direct target of microRNA-9 in medulloblastoma, and restoration of microRNA-9 was shown to trigger cell cycle arrest, to inhibit clonal growth and to promote medulloblastoma cell differentiation. 24346283 2014
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.050 Biomarker disease BEFREE Micro-RNA (miR) 199b-5p targets Hes1 in medulloblastoma, one of the downstream effectors of both the canonical Notch and noncanonical Sonic Hedgehog pathways. 22411914 2012
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.050 AlteredExpression disease BEFREE MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. 19308264 2009
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.050 AlteredExpression disease BEFREE Notch pathway overactivity was demonstrated in the TE671 MB cell line expressing high levels of MSH1 through HES1-Luciferase transfections. 15064731 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.050 Biomarker disease BEFREE In addition, expression of the Notch pathway target gene Hes1 in medulloblastomas was associated with significantly shorter patient survival (P = 0.01). 15520184 2004