HES1, hes family bHLH transcription factor 1, 3280

N. diseases: 243; N. variants: 0
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE These findings indicate that carcinogenesis in a subset of colon cancer is consequent to a molecular mechanism driven by fucosylation deficiency and/or HES1-loss. 27639802 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 AlteredExpression disease BEFREE Colon cancer cell lines which over-expressed HES1 were more resistant to 5-Fu treatment <i>in vitro</i>. 28928869 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE Our results provide functional and mechanistic links between Hes1 and Bmi-1/PTEN/Akt/GSK3β signaling in the development and progression of colon cancer. 26452029 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE Taken together, our data indicate that Hes1 induces stem-like cell self-renewal and increases the number of tumour-initiating cells in colon cancer. 24492635 2014
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 AlteredExpression disease BEFREE We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance. 19147571 2009