Disease: Adrenal Gland Hyperfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 AlteredExpression phenotype BEFREE Alleviating 11β-HSD1 activity is therefore a logical and common way to treat hyperadrenalism. 30021644 2018
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 AlteredExpression phenotype BEFREE Hypercortisolemia at the systemic (Cushing's syndrome) or local levels (due to adipose-specific overproduction via 11β-hydroxysteroid dehydrogenase 1) results in the preferential expansion of central, especially visceral fat depots. 23735216 2014
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 Biomarker phenotype BEFREE Extra-adrenal cortisol production by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) can result in local hypercortisolemia. 22433622 2012
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 GeneticVariation phenotype BEFREE The potential importance of gene variants coding HSD11B has not been previously evaluated in patients with endogenous hypercortisolism. 21111044 2011
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 Biomarker phenotype BEFREE The overexpression of liver reductases in obesity could be an adaptive response to an increase in cortisol production by the liver and visceral 11β-HSD1 to avoid systemic hypercortisolism. 21704348 2011
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.060 GeneticVariation phenotype BEFREE HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia. 19651257 2009