HSF1, heat shock transcription factor 1, 3297

N. diseases: 185; N. variants: 4
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.030 Biomarker disease BEFREE Hsf1 ablation suppresses the growth of human T-ALL and eradicates leukemia in mouse models of T-ALL, while sparing normal hematopoiesis. 30038221 2018
CUI: C0023418
Disease: leukemia
leukemia 		0.030 Biomarker disease BEFREE Collectively, our results identify a novel mechanism by which oridonin induces rapid degradation of BCR-ABL as well as a novel pharmaceutical activator of HSF1 that represents a promising treatment for leukemia. 28128329 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.030 Biomarker disease BEFREE Inhibition of both mTOR and PIM counteracted induction of heat-shock family proteins, uncovering the master negative regulation of heat shock factor 1 (HSF1), the dominant transcription factor controlling cellular stress responses. 26473447 2015