HSF1, heat shock transcription factor 1, 3297

N. diseases: 185; N. variants: 4
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease BEFREE In vivo, HSF1 antagonizes AMPK to control body fat mass and drive the lipogenic phenotype and growth of melanomas independently of its intrinsic transcriptional action. 31561952 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease BEFREE Active heat shock transcription factor 1 supports migration of the melanoma cells via vinculin down-regulation. 25435429 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease BEFREE Overall, these results show that HSF1 is indispensable for melanoma progression and metastasis, and suggests that HSF1 could be a promising therapeutic target for melanoma. 25194503 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.050 AlteredExpression disease BEFREE HSF1 overexpression facilitates the survival of melanoma cells treated with doxorubicin or paclitaxel. 24165036 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.050 Biomarker disease BEFREE These findings show that HSF1 is required for normal growth and survival of melanoma cells under heat shock conditions, and suggests that HSF1 is a promising therapeutic target in melanoma. 21044828 2010