HSF1, heat shock transcription factor 1, 3297

N. diseases: 185; N. variants: 4
Disease: Motor disturbances ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2220255
Disease: Motor disturbances
Motor disturbances 		0.010 AlteredExpression phenotype BEFREE Conversely, pharmacological activation of HSF1 transcription factor and enhanced expression of inducible HSP70 with the echinochrome derivative, U-133, reverses the process of neurodegeneration, as evidenced by а increase in the number of tyrosine hydroxylase-containing neurons, and prevents the motor disturbances that are typical of the clinical stage of the disease. 29704482 2018