|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined five cases of API2-MALT1 fusion-positive MALT lymphoma of the lung.
|
27600807 |
2016 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways.
|
27452667 |
2016 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.
|
25569716 |
2015 |
|
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the c-IAP2/MALT1 fusion protein activates NF-κB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.
|
21048983 |
2010 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As we observed MALT1-API2 to be an efficient target of its own E3 ubiquitin ligase activity, our data suggest that this inherent instability of MALT1-API2 prevents its accumulation and renders a potential effect on MALT lymphoma development via destabilization of BCL10 unlikely.
|
19279678 |
2009 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significantly, 98% of all cIAP2-MALT1 fusion proteins retain the UBA domain, suggesting that ubiquitin-binding contributes to the oncogenic potential of cIAP2-MALT1 in MALT lymphoma.
|
18931663 |
2008 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
API2-MALT1 fusion transcript does not appear to be associated with either histological variant of primary intraoral MALT lymphoma.
|
18158571 |
2007 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We assessed the incidence and clinical significance of the MALT lymphoma-associated genetic abnormalities t(11;18)/API2-MALT1, t(1;14)/BCL10-IGH, t(14;18)/IGH-MALT1, t(3;14)/FOXP1-IGH, and extra copies of MALT1 and FOXP1 in gastric MALT lymphomas from Japan.
|
17525089 |
2007 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Helicobacter pylori-negative / API2-MALT1 translocation-negative low-grade MALT lymphoma.
|
16952043 |
2006 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
API2-MALT1 translocation was detected in 1 (7%) of 14 DLBCL cases and in 1 (17%) of 6 MALT lymphoma cases.
|
16484127 |
2006 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data support the hypothesis that the API2-MALT1 fusion protein can contribute to MALT lymphoma formation via increased NF-kappaB activation.
|
16707452 |
2006 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular pathogenesis of MALT lymphoma: two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein.
|
16572204 |
2006 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One hundred thirty-three paraffin-embedded North American primary MALT lymphoma specimens from diverse anatomic sites were studied by fluorescence in situ hybridization (FISH) using probes for API2-MALT1, IGH-MALT1, IGH-BCL10, IGH-FOXP1, IGH, +/- centromeres 3, 7, 12, and 18, and a subset (n=74) were analyzed using FISH probes for IGK, IGL, and BCL6.
|
17122510 |
2006 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most frequent chromosome translocation associated with MALT lymphoma is t(11;18)(q21;q21), which generates a chimeric protein of c-IAP2 and MALT1/paracaspase.
|
15894263 |
2005 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This stability of API2-MALT1 may thus result in inappropriate nuclear factor (NF)-kappaB activation, thereby contributing to the pathogenesis of MALT lymphoma.
|
15711920 |
2005 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The API2-MALT1 fusion was detected by multiplex reverse transcription polymerase chain reaction in 25/60 (42%) cases of MALT lymphoma, but none of 11 DLBLs.
|
15832193 |
2005 |
|
Familial primary gastric lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The detection of API2-MALT1 fusion as carried out with these specimens would be useful as an ancillary assay for the diagnosis, staging, and follow-up of pulmonary MALT lymphoma.
|
16105761 |
2005 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
API2-MALT1 fusion and aneuploidy are common chromosomal abnormalities in MALT lymphoma.
|
14574335 |
2004 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule.
|
12651604 |
2003 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma.
|
14681324 |
2003 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18) (q21;q21) MALT lymphoma.
|
14603249 |
2003 |
|
Familial primary gastric lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 13 samples of MALT lymphoma contained API2-MALT1 transcripts from 1.7 x 10(-2) to 1.0 copies/beta-actin copy.
|
14562112 |
2003 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Borrelia burgdorferi infection has been suggested as a possible causative agent in European cutaneous cases of marginal zone B-cell lymphoma, whereas API2-MALT1 fusion and BCL10 mutation are highly associated with MALT lymphoma.
|
12883238 |
2003 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using this rapid and simple method, we could detect API2-MALT1 fusion transcripts in 5 of 15 (33%) archival cases of MALT lymphoma for a frequency comparable with those of RT-PCR assays using frozen materials.
|
11159207 |
2001 |
|
Familial primary gastric lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To gain some insight into the mechanism that generates this translocation, we cloned and sequenced an API2-MALT1 fused transcript as well as genomic DNA of the t(11;18) translocation from a MALT lymphoma.
|
11162514 |
2001 |