|
Middle Cerebral Artery Occlusion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the effect of HSP70-hom+2437 single nucleotide polymorphisms (SNPs) on hypoxia and ischemia condition, we constructed the neuronal hypoxic injury model and the rat middle cerebral artery occlusion (MCAO) model to compare the inhibition rate of neurons and detect the infarct volume as well as the expression of related apoptotic proteins in order to explore the possible mechanisms.
|
31170438 |
2019 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We carried out a case-control study among 367 coke oven workers in northwest China, focused on three common HSP70 polymorphisms (HSP70-1 G190C, HSP70-2 A1267G and HSP70-hom T2437C), and evaluated the association of HSP70 gene polymorphisms with work sites for high risk of hypertension.
|
30217924 |
2018 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for BD in vulnerable populations.
|
28291257 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In a CRC cell line and human CRC tissue exposed to hypoxia, induced heat-shock 70-kDa protein-1-like (HSPA1L) expression stabilized hypoxia-inducible factor-1α (HIF-1α) protein and promoted PrP<sup>C</sup> accumulation and tumorigenicity in vivo.
|
28759037 |
2017 |
|
Inflammatory Bowel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that de novo and rare mutations in HSPA1L are associated with IBD and provide insights into the pathogenesis of IBD, and also expand our understanding of the roles of HSP70s in human disease.
|
28126021 |
2017 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that the HSPA1L/HIF-1α/GP78 axis has a crucial role in PrP<sup>C</sup> accumulation during tumor progression.
|
28759037 |
2017 |
|
Deep caries
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Overall, SNPs in HSPA1L and HSPA6 showed significant allelic association with cases of deep caries and periapical lesions (P < .05).
|
27567034 |
2016 |
|
Tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of IL-6, STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study.
|
25789467 |
2015 |
|
Pemphigus Foliaceus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We analyzed by PCR-RFLP polymorphisms of HSP70 genes HSA1A, HSPA1B and HSPA1L in 80 Tunisian patients with PF, 160 matched healthy controls and 147 related healthy subjects.
|
25687737 |
2015 |
|
Chronic graft-versus-host disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our initial results in this small cohort show that quantifying HSPA1L mRNA expression in the whole blood of allo-HSCT patients at day 28 post-allo-HSCT may be a useful predictive biomarker for cGVHD.
|
25680846 |
2015 |
|
Hepatitis, Drug-Induced
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of IL-6, STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study.
|
25789467 |
2015 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the HSPA1L (rs2075800) TT genotype was associated with susceptibility to IPF (OR = 2.52, 95 % CI = 1.32-4.81; p = 0.005).
|
26496868 |
2015 |
|
Hepatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
The risk for the development of CH and HCC compared to healthy controls irrespective of the aetiology was significant in terms of the HSPA1B marker than HSPA1L in the Indian population.
|
23490384 |
2013 |
|
Cataract
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of the polymorphisms in HSPA1A, HSPA1B, and HSPA1L genes in the HSPs repair pathway with the risk of cataract in a Chinese population.
|
23666708 |
2013 |
|
Complete atrioventricular block
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of HSPA1L BB genotype and B allele in HCC were more than in CH [odds ratio (OR): 9.83; P = 0.000], but also in HBV-related HCC than Chronic Hepatitis B (CHB) [OR: 3.44; P = 0.004] and HCV-related HCC compared to CHC [OR: 6.32; P = 0.010].
|
23490384 |
2013 |
|
Hepatitis B, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of HSPA1L BB genotype and B allele in HCC were more than in CH [odds ratio (OR): 9.83; P = 0.000], but also in HBV-related HCC than Chronic Hepatitis B (CHB) [OR: 3.44; P = 0.004] and HCV-related HCC compared to CHC [OR: 6.32; P = 0.010].
|
23490384 |
2013 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The risk for the development of CH and HCC compared to healthy controls irrespective of the aetiology was significant in terms of the HSPA1B marker than HSPA1L in the Indian population.
|
23490384 |
2013 |
|
Anthracosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genotyping results of this study indicate that the G allele distribution of HSP70-2, the genotype frequency of HSP70-hom poly-morphisms and some haplotypes of the HSP70 genes are associated with the susceptibility to and severity of CWP, and may be involved in the pathogenesis and development of CWP in the southwestern Chinese Han population.
|
21471543 |
2011 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To systematically evaluate their associations with childhood acute lymphoblastic leukemia (ALL), we examined the three functional single nucleotide polymorphisms (SNPs) rs2227956 (rs2227956" genes_norm="3305">T493M) in HSPA1L, rs1043618 in HSPA1A 5'UTR, and rs1061581 (Q351Q) in HSPA1B by TaqMan assays or polymerase chain reaction-restriction fragment length polymorphism in 114 ALL cases and 414 controls from Wales (UK), in 100 Mexican Mestizo ALL cases and 253 controls belonging to the same ethnic group, and in a panel of 82 HLA-typed reference cell line samples.
|
20012387 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
On analysis of common genetic variants of HspA1L, HspA1A and HspA1B, a haplotype significantly associated with SLE in the Erlangen-SLE cohort was identified, which was confirmed in the OMRF cohort.
|
20498198 |
2010 |
|
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated HSP70-1 G+190C, HSP70-2 A+1267G, and HSP70-hom T+2437C polymorphisms to assess whether genetic variation in HSP70 plays a role in the occurrence and development of lung cancer.
|
20704535 |
2010 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated HSP70-1 G+190C, HSP70-2 A+1267G, and HSP70-hom T+2437C polymorphisms to assess whether genetic variation in HSP70 plays a role in the occurrence and development of lung cancer.
|
20704535 |
2010 |
|
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated HSP70-1 G+190C, HSP70-2 A+1267G, and HSP70-hom T+2437C polymorphisms to assess whether genetic variation in HSP70 plays a role in the occurrence and development of lung cancer.
|
20704535 |
2010 |
|
High altitude pulmonary edema
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We focused on 5 common polymorphisms within HSPA1A (rs1043618 and rs1008438), HSPA1B (rs1061581 and rs539689) and HSPA1L (rs2227956) of Hsp70 family to explore their potential interaction upon susceptibility to HAPE in Chinese.
|
19351530 |
2009 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data show that a mutation in hsp70-Hom gene is associated with higher incidence of PoAF.
|
17934269 |
2008 |