BIRC5, baculoviral IAP repeat containing 5, 332

N. diseases: 199; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699893
Disease: Skin carcinoma
Skin carcinoma 		0.010 AlteredExpression disease BEFREE Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. 10496530 1999
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.030 AlteredExpression disease BEFREE Here, we investigated the mutual expression of the Survivin/EPR-1 genes in 12 normal peripheral blood (PB) specimens, seven normal bone marrow (BM) specimens, five lymph node (LN) specimens, and seven leukemic cell lines, and 27 patients with malignant lymphoma (ML), four with acute lymphocytic leukemia (ALL), three with acute myelocytic leukemia (AML), and four with chronic myelocytic leukemia in blastic crisis (CML-BC). 11086180 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.030 AlteredExpression group BEFREE Here, we investigated the mutual expression of the Survivin/EPR-1 genes in 12 normal peripheral blood (PB) specimens, seven normal bone marrow (BM) specimens, five lymph node (LN) specimens, and seven leukemic cell lines, and 27 patients with malignant lymphoma (ML), four with acute lymphocytic leukemia (ALL), three with acute myelocytic leukemia (AML), and four with chronic myelocytic leukemia in blastic crisis (CML-BC). 11086180 2000
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.020 AlteredExpression disease BEFREE Here, we investigated the mutual expression of the Survivin/EPR-1 genes in 12 normal peripheral blood (PB) specimens, seven normal bone marrow (BM) specimens, five lymph node (LN) specimens, and seven leukemic cell lines, and 27 patients with malignant lymphoma (ML), four with acute lymphocytic leukemia (ALL), three with acute myelocytic leukemia (AML), and four with chronic myelocytic leukemia in blastic crisis (CML-BC). 11086180 2000
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.020 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma 		0.020 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.010 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0152268
Disease: Nodular Sclerosis Classical Hodgkin Lymphoma
Nodular Sclerosis Classical Hodgkin Lymphoma 		0.010 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma 		0.010 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0220644
Disease: Childhood Hodgkin Lymphoma
Childhood Hodgkin Lymphoma 		0.010 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.010 Biomarker group BEFREE Disturbed expression of the anti-apoptosis gene, survivin, and EPR-1 in hematological malignancies. 11086180 2000
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.010 AlteredExpression disease BEFREE No EPR-1 expression with or without Survivin expression was clearly detected in eight of the nine diffuse large B-cell lymphoma (DLB) specimens, two of the six follicular center lymphoma specimens, one of the four specimens of nodular sclerosis of Hodgkin's lymphoma, two of the four ALL specimens or one of the four CML-BC specimens. 11086180 2000
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.390 Biomarker disease BEFREE In this study, we investigated the potential expression and prognostic significance of the apoptosis inhibitor survivin in squamous cell carcinoma (SCC). 11418003 2001
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.390 GeneticVariation disease BEFREE Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostate, lung, and colorectal cancer. 11581299 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Tumors injected with pAd-T34A exhibited loss of proliferating cells and massive apoptosis by in situ internucleosomal DNA fragmentation. 11581299 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE A role of apoptosis (programmed cell death) in tumor formation and growth was investigated by targeting the apoptosis inhibitor survivin in vivo. 11149963 2001
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.060 GeneticVariation disease BEFREE Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostate, lung, and colorectal cancer. 11581299 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 AlteredExpression disease LHGDN Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. 12374680 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.390 AlteredExpression disease LHGDN Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications. 12174930 2002
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.370 AlteredExpression group LHGDN Increased expression of survivin in gastric cancer patients and in first degree relatives. 12085263 2002
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.370 AlteredExpression group LHGDN Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment. 11773702 2002
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.360 AlteredExpression group LHGDN Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas. 12168867 2002
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.340 AlteredExpression disease LHGDN Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas. 12115583 2002
CUI: C0017638
Disease: Glioma
Glioma 		0.250 AlteredExpression disease LHGDN Quantitatively determined survivin expression levels are of prognostic value in human gliomas. 11844831 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.070 Biomarker disease LHGDN The survivin:Fas ratio is predictive of recurrent disease in neuroblastoma. 11877677 2002