BIRC5, baculoviral IAP repeat containing 5, 332

N. diseases: 199; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE Tumors injected with pAd-T34A exhibited loss of proliferating cells and massive apoptosis by in situ internucleosomal DNA fragmentation. 11581299 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study? 31439015 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study? 31439015 2019
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.030 AlteredExpression disease BEFREE BIRC5 expression, which is strong in all MBs and absent in normal cerebellum, lacks any prognostic value but could be explored for selective targeting of therapeutic factors to MBs. 15488319 2004
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.030 AlteredExpression group BEFREE BIRC5/Survivin expression, in contrast to BCL2, was associated with a signature of cell proliferation (overexpression of cell cycle control, DNA repair, and polymerase genes), which may contribute to the aggressive phenotype and poor prognosis of these lymphomas. 15880597 2005
CUI: C0026499
Disease: Monosomy
Monosomy 		0.010 AlteredExpression group BEFREE BIRC5 levels correlated with presence of monosomy 3 (p = 0.01) and higher levels of BIRC7 correlated with epithelioid cell type (p = 0.048). 18853322 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.340 AlteredExpression disease BEFREE BIRC5 mRNA was also significantly different between patients with Stage III and Stage IV non-small cell lung cancers. 19585499 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.070 AlteredExpression disease BEFREE BIRC5 is strongly over expressed in neuroblastoma tumour samples, which correlates to a poor prognosis. 22088485 2012
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE BIRC5 is strongly over expressed in neuroblastoma tumour samples, which correlates to a poor prognosis. 22088485 2012
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.040 AlteredExpression disease BEFREE BIRC5 is strongly over expressed in neuroblastoma tumour samples, which correlates to a poor prognosis. 22088485 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE BIRC5 is strongly over expressed in neuroblastoma tumour samples, which correlates to a poor prognosis. 22088485 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Baculoviral IAP repeat containing 5 (BIRC5) (also known as survivin) is an important anti-apoptotic protein that has been implicated in many cancer types, and recent studies provide evidence for its role in controlling inflammatory disorders as well. 22336533 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Baculoviral IAP repeat containing 5 (BIRC5) (also known as survivin) is an important anti-apoptotic protein that has been implicated in many cancer types, and recent studies provide evidence for its role in controlling inflammatory disorders as well. 22336533 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE BIRC5 and hTERT, markers of tumor survival, were up-regulated in CS as compared with normal counterparts. 23932095 2013
CUI: C0280630
Disease: Uterine Carcinosarcoma
Uterine Carcinosarcoma 		0.010 AlteredExpression disease BEFREE BIRC5 and hTERT, markers of tumor survival, were up-regulated in CS as compared with normal counterparts. 23932095 2013
CUI: C1704376
Disease: Uterine Corpus Carcinosarcoma
Uterine Corpus Carcinosarcoma 		0.010 AlteredExpression disease BEFREE BIRC5 and hTERT, markers of tumor survival, were up-regulated in CS as compared with normal counterparts. 23932095 2013
CUI: C0220621
Disease: Childhood Acute Myeloid Leukemia
Childhood Acute Myeloid Leukemia 		0.010 AlteredExpression disease BEFREE BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. 24127439 2014
CUI: C0677932
Disease: Progressive Neoplastic Disease
Progressive Neoplastic Disease 		0.010 AlteredExpression phenotype BEFREE BIRC5 upregulation was linked to stable disease (SD) or progressive disease (PD). 26537080 2016
CUI: C3539781
Disease: Progressive cGVHD
Progressive cGVHD 		0.010 AlteredExpression disease BEFREE BIRC5 upregulation was linked to stable disease (SD) or progressive disease (PD). 26537080 2016
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 GeneticVariation disease BEFREE BIRC5 -31C>G polymorphism could be useful pharmacogenetic marker for methotrexate treatment response in RA. 26651826 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 Biomarker disease BEFREE BIRC5 (survivin): a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy. 27592112 2016
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.020 Biomarker disease BEFREE BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. 31059751 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.020 Biomarker disease BEFREE BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. 31059751 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE BIRC5/Survivin is known as a dual cellular functions protein that directly regulates both apoptosis and mitosis in embryonic cells during embryogenesis and in cancer cells during tumorigenesis and tumor metastasis. 31612776 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 Biomarker phenotype BEFREE BIRC5/Survivin is known as a dual cellular functions protein that directly regulates both apoptosis and mitosis in embryonic cells during embryogenesis and in cancer cells during tumorigenesis and tumor metastasis. 31612776 2019