|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
These genes are functionally involved with virus process (F13A1 and HSP90AB1), immunity (ABCB1LB, RGS5, C10ORF58, OSF-2, MMP7, CXCL12, GAL1, GAL2, GAL7, HVCN1, PDE4D, IL4I1, PARP9, EOMES, MPEG1, PDK4, CCLI10, K60 and FST), and tumor suppression (ADAMTS2, LXN, ARRDC3, WNT7A, CLDN1 and HPGD).
|
31578366 |
2019 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We carried out preliminary genetic characterisation by whole exome sequencing and detected tumor specific mutations in Hsp90ab1, Ccnb3 and RhoA.
|
31013298 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Results of in vitro analysis indicate that Hsp90β enhances the tumor VM in tumor-burdened mice, and the Hsp90 inhibitor NVP-BEP800 suppresses VM formation by releasing Hsp90β and Twist1 interaction.
|
30087438 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The downregulation of HSP90AB1 was confirmed at the protein level in these cell lines as well as in colorectal and mammary tumors in mice with tissue-specific Usp22 deletions.
|
31801945 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor.
|
30522463 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Histological analysis was performed on tumor samples to evaluate Hsp90β, VEGFRs expression and MVD.
|
28359326 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
17-AAG, a heat shock protein 90 (HSP-90) inhibitor, was shown to modulate the expression of several diverse cancer-associated genes, including ADAMTS1, part of the query signature, and maspin, an HSP-90-associated protein with a tumor suppressor role in HCC.
|
19514085 |
2009 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
A third cluster that included HSP-90 tended to be associated with clinical tumor stage, whereas a forth cluster that included keratin 14 tended to be associated with tumor size.
|
10786689 |
2000 |