Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, a Gaussian pdf is not adequate to approximate the noise in array CGH data and hence introduces wrong detections of chromosomal aberrations and leads misunderstanding on disease pathogenesis.
|
28692986 |
2019 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients with atypical values of HCG and/or PAPP-A are at higher risk of chromosomal abnormality and vascular complications of pregnancy.
|
31779618 |
2019 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
SNP array, array CGH and FISH were useful for the complete characterization of the chromosomal aberrations, for the detection of microdeletions in patients with normal karyotype but with strong clinical suspicious of chromosomal alteration, and for a better establishment of genotype-phenotype correlation.
|
31730496 |
2019 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic screening for chromosomopathy is performed in the first trimester of pregnancy by determining fetal nuchal translucency (NT), and the pregnancy associated plasma protein-A (PAPP-A) and free human chorionic gonadotropin (free-beta HCG) biomarkers in maternal serum.
|
30581343 |
2018 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The main databases devoted stricto sensu to cancer cytogenetics are the "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer" ( http://cgap.nci.nih.gov/Chromosomes/Mitelman ), the "Atlas of Genetics and Cytogenetics in Oncology and Haematology" ( http://atlasgeneticsoncology.org ), and COSMIC ( http://cancer.sanger.ac.uk/cosmic ).However, being a complex multistep process, cancer cytogenetics are broadened to "cytogenomics," with complementary resources on: general databases (nucleic acid and protein sequences databases; cartography browsers: GenBank, RefSeq, UCSC, Ensembl, UniProtKB, and Entrez Gene), cancer genomic portals associated with recent international integrated programs, such as TCGA or ICGC, other fusion genes databases, array CGH databases, copy number variation databases, and mutation databases.
|
27910033 |
2017 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Using array-CGH, the present study aimed to explore genome-wide profiles of chromosomal aberrations in samples of oral cancer (OC), oral submucous fibrosis (OSF) and their corresponding normal oral mucosa from Indian (n=18) and OC from Sri Lankan (n=12) patients with history of BQ use, and correlate the findings to other clinicopathological parameters.
|
24969693 |
2015 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Array CGH revealed shared chromosomal aberrations in the patient tumors and PDX.
|
26041878 |
2015 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Array-CGH analysis allowed for a higher rate of detection of chromosomal anomalies, and this determination is especially valuable in neonates with congenital anomalies of unknown etiology, or in cases in which karyotype results cannot be obtained.
|
25203518 |
2015 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genome-wide screening of cytogenetic abnormalities in multiple myeloma patients using array-CGH technique: a Czech multicenter experience.
|
24987674 |
2014 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Eighteen children with acute myeloid leukemia (AML) (n=15) or myelodysplastic syndrome (MDS) (n=3) were studied using CGH+SNP microarray to evaluate the clinical significance of submicroscopic chromosomal aberrations.
|
25045224 |
2014 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Our array CGH analysis detected an average of 83 chromosomal aberrations in 13 cases, ranging from 0 to 387.
|
24952511 |
2014 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytogenetic abnormality was investigated with FISH and array-CGH to characterize the breakpoints of the complex rearrangement.
|
22965227 |
2013 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Monozygotic twins discordant for submicroscopic chromosomal anomalies in 2p25.3 region detected by array CGH.
|
23061379 |
2013 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Etiologic influence on chromosomal aberrations in European hepatocellular carcinoma identified by CGH.
|
23706943 |
2013 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
More chromosome abnormalities are detected by conventional karyotyping compared to FISH or MLPA only (chromosome region specific techniques), and the same amount of abnormalities compared to QF-PCR (chromosome region specific techniques) and chromosomal-CGH and array-CGH (whole genome techniques) only.
|
22796359 |
2012 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Fast approach for clarification of chromosomal aberrations by using LM-PCR and FT-CGH in leukaemic sample.
|
21986343 |
2012 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The clustering of MSI-H tumors in global CGH data analysis suggests that chromosomal aberrations are not random.
|
22879877 |
2012 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Chromosomal aberrations in bladder cancer: fresh versus formalin fixed paraffin embedded tissue and targeted FISH versus wide microarray-based CGH analysis.
|
21909424 |
2011 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Unlike metaphase CGH, the high resolution of array CGH in subtelomeric regions allows an accurate description of chromosomal aberrations.
|
21145667 |
2011 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show that the use of oligonucleotide-based array- CGH in a clinical diagnostic laboratory increases the detection rate of pathogenic submicroscopic chromosomal aberrations in patients with mental retardation and congenital abnormalities, but it also presents challenges for clinical interpretation of the results (i.e., distinguishing between pathogenic and benign variants).
|
22123463 |
2011 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of chromosomal aberrations from a single cell by array comparative genomic hybridization (single-cell array CGH), instead of from a population of cells, is an emerging technique.
|
21854607 |
2011 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The database is the first comprehensive integration of disparate cancer genome data like single nucleotide variants, single nucleotide polymorphisms, and chromosomal aberrations (CGH and FISH).
|
20127971 |
2010 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Array CGH analysis revealed a significant correlation between LINE-1 hypomethylation and chromosomal aberrations.
|
20978145 |
2010 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
To explore the advantages and limitations of comparative genomic hybridization to BAC arrays (array CGH) for prenatal diagnosis of a fetus with anomalies and a chromosome abnormality.
|
18818501 |
2008 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Screening large patient cohorts with mental retardation by array CGH has recently lead to the characterization of many novel microdeletion and microduplication syndromes, initially according to the shared cytogenetic aberrations, with secondary characterization of the corresponding phenotypes.
|
18512078 |
2008 |