|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
It may be induced by apoA-1 on the surface of HCV lipoviral particles.
|
29423541 |
2018 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
We selected 22 SNPs in five lipid regulator genes which were related to HCV entry into hepatocytes and to lipid metabolism (APOA1, APOB, SR-B1, LDLR, and APOE), and their polymorphisms were analyzed using the PCR-sequence-specific oligonucleotide probe-Luminex method.
|
29382324 |
2018 |
|
Hepatitis C
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Treatment with these compounds and 25-(OH)D<sub>3</sub> suppressed the expression of apolipoprotein A1 and C3, which are known to be involved in infectious virus production of HCV, and the knockdown of these apolipoproteins reduced infectious virus production.
|
30339849 |
2018 |
|
Hepatitis C
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The siRNA-mediated knockdown of apoE, apoA1, and apoB expression also suppressed the RNA replication of HCV genotype 1b, but not that of HCV genotype 2a.
|
27225463 |
2016 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
There were no similar associations between miR-122 and ApoA-1 or between HCV RNA and lipoproteins.
|
25963774 |
2015 |
|
Hepatitis C
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Although Huh7 cells deficient in either ApoB or ApoE gene exhibited slight reduction of particles formation, knockout of both ApoB and ApoE genes in Huh7 (DKO) cells severely impaired the formation of infectious HCV particles, suggesting that ApoB and ApoE have redundant roles in the formation of infectious HCV particles. cDNA microarray analyses revealed that ApoB and ApoE are dominantly expressed in Huh7 cells, in contrast to the high level expression of all of the exchangeable apolipoproteins, including ApoA1, ApoA2, ApoC1, ApoC2 and ApoC3 in human liver tissues.
|
25502789 |
2014 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, miR-27a repressed the expression of many lipid metabolism-related genes, including FASN, SREBP1, SREBP2, PPARα, and PPARγ, as well as ApoA1, ApoB100, and ApoE3, which are essential for the production of infectious viral particles. miR-27a repression increased the cellular lipid content, decreased the buoyant density of HCV particles from 1.13 to 1.08 g/cm(3), and increased viral replication and infectivity. miR-27a overexpression substantially decreased viral infectivity.
|
23449803 |
2013 |
|
Hepatitis C
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In 50 patient samples (24 HCV and 26 HCC), all three SRM assays yielded highly similar differential expression of ApoA1 in HCC and HCV patients.
|
24008390 |
2013 |
|
Hepatitis C
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results established an association of NS5A with lipid droplets and apoA1, suggesting that NS5A, together with the core protein, may play a role in the pathogenesis of the derangement of lipid metabolism, contributing to liver steatosis commonly observed in hepatitis C.
|
11878923 |
2002 |