|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the effect of dalcetrapib treatment on phytosterol levels in patients with familial combined hyperlipidemia (FCH) or familial hypoalphalipoproteinemia (FHA) due to mutations in apolipoprotein A1 (ApoA1) or ATP-binding cassette transporter A1 (ABCA1).
|
25281277 |
2014 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese.
|
19732897 |
2010 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation suggests that the low HDL-C/low Apo A-I phenotype may result from a genetic defect directly affecting HDL metabolism, even in the context of a dyslipidemia which, like FCHL, is associated with low plasma HDL-C.
|
17950741 |
2008 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
Biomarker
|
disease |
LHGDN |
Patients with FCHL have increased carotid IMT that is strongly related to the apoB/apoA-I ratio, a measure of overall lipid abnormalities.
|
17698072 |
2008 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein A1 provided an OR of 0.95 (0.94-0.97, P<0.001) in FCHL families and OR of 0.94 (0.90-0.97, P=0.011) in FH families, but neither in FHTG nor in normolipidemic families (both P>0.05).
|
16828905 |
2007 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Apo AI levels tended to be low in FCHL and were decreased in 'coronary disease with low-HDL cholesterol'.
|
16629853 |
2006 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, several candidate gene studies have replicated the influence of the lipoprotein lipase (LPL) gene and apolipoprotein A1/C3/A4/A5 (APOA1/C3/A4/A5) gene cluster in FCHL.
|
16938803 |
2006 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combined linkage and association analyses provide compelling evidence for the involvement of two distinct alleles at the APOA1/C3/A4/A5 gene cluster in the transmission of FCHL.
|
14764618 |
2004 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A combined linkage and association analysis establishes that variation at the APOA1/C3/A4/A5 gene cluster contributes to FCHL transmission in a substantial proportion of northern European families.
|
14551155 |
2004 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.
|
15001527 |
2004 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, analysis of four candidate genes putatively involved in the expression of FCHL showed no evidence of linkage for the LCAT gene or the APOA1/C3/A4/A5 gene cluster.
|
15469419 |
2004 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linkage and association of the apo AI-CIII-IV gene region to familial combined hyperlipidemia (FCHL) was reported previously, based on the presence of genetic variants in the apo CIII and apo AI gene.
|
11583715 |
2001 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, previously reported linkage of FCHL to apolipoprotein A-I/C-III/A-IV has been investigated in FHS families.
|
11031215 |
2000 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia.
|
9812922 |
1998 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.
|
9062353 |
1997 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variation at the APO AI-CIII-AIV gene cluster and familial combined hyperlipidaemia.
|
7889654 |
1994 |
|
Hyperlipidemia, Familial Combined
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The other 44 FDH patients without FCHL had 33% lower HDL (p = 0.0001), with only 8% lower apolipoprotein A-I levels (p = 0.20); significantly higher subscapular skinfolds (p = 0.02), weights (p = 0.002), body mass index (p = 0.006), knee widths (p = 0.0007), and wrist circumferences (p = 0.0009); smaller, denser LDL subfractions (p = 0.001); and increased apolipoprotein B levels (p = 0.01) compared to the normolipidemic hypertensive group.
|
2497719 |
1989 |