|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment as a dependent variable.
|
21449006 |
2011 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.
|
30664620 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In our study, the HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.
|
21512427 |
2011 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Specifically, we investigated two serotonin-related genes including three substitutions connected to human emotional states such as despondency and depression: the tryptophan hydroxylase (TPH) gene (A779C and A218C in the intron) and the serotonin1A (5-HT1A) receptor gene (Pro 16Leu in the cording region).
|
14998306 |
2004 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
This article targets the 5-HT1A receptors to show that indiscriminate activation of pre and postsynaptic 5-HT1A receptors is likely to produce no therapeutic benefits; biased activation of the 5-HT heteroreceptors may be a useful strategy for treating chronic pain and depression individually as well as in a comorbid condition.
|
31418663 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.
|
30301302 |
2018 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Patients carrying the HTR1A CC genotype and the COMT Val/Val genotype (HR = 3.25) had a higher risk of depression than patients with the G allele (HTR1A) and the Val/Val genotype.
|
26721949 |
2016 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These studies implicate transcriptional dysregulation of 5-HT1A autoreceptors by the repressor Freud-1 in anxiety and depression and provide a clinically relevant genetic model of antidepressant resistance.
|
29101244 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The diagnosis of current depression, which was associated with IFN-α-related depression (P<.001), demonstrated a statistically significant association with the CC genotype of the 5-HTR1A gene (odds ratio=5.57, 95% confidence interval=1.61-19.24, P=.007).
|
24462335 |
2015 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Several studies have demonstrated the involvement of 5-HT1A receptors in the pathogenesis of depression and in the antidepressant response to SSRIs.
|
15458611 |
2004 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The predictors of delayed remission included unemployment (P = .004), severe medical comorbidity (P < .0001), severe baseline depression (P < .0001), more than 4 dysthymic symptoms (P = .005), more than 9 posttraumatic stress symptoms (P = .005), and serotonin receptor 1A (P = .006) and cytochrome P450 2D6 (P = .002 for C/T and P = .0004 for T/T) genetic variants.
|
29178685 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We present evidence that by targeting specific transcription factors it may be possible to oppositely regulate 5-HT1A auto- and heteroreceptor expression, synergistically increasing serotonergic neurotransmission for the treatment of depression.
|
24180393 |
2014 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression.
|
11704418 |
2001 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The serotonin1A (5-HT1A) receptor has been under intense investigation, mostly due to its putative role in both the etiology and therapeutic treatments of depression and anxiety-related behaviors.
|
11742136 |
2001 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
AN have higher 5-HT(1A) than controls and AE suggesting a model of depression characterized by an over expression of autoinhibitory somatodendritic 5-HT(1A) receptors, perhaps due to the higher expressing G allele, that may result in reduced terminal field 5-HT release.
|
16154547 |
2006 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Subgroups of 43 patients with LMD, 96 with HTR1A-G allele, and 12 with both LMD and HTR1A-G homozigosity scored significantly higher to depression compared to the remaining patients during antiviral therapy.
|
26001668 |
2015 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
While the study has several limitations, the results are consistent with a growing body of literature that suggests that the pharmacogenetics of depression (an inherently complex disorder) may turn out to be multifactorial, and may include the HTR1A gene in concert with other serotonin-related genes.
|
17570737 |
2007 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders.
|
18639564 |
2008 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The 5-HT1A receptor is a pharmacologically well characterized serotonin receptor subtype and it has long been investigated because of its involvement in several physiopathological mechanisms and treatment of neurological diseases like ansia and depression.
|
29424302 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our findings support the hypothesis that changes in efficacy of serotonergic neurotransmission in this model of depression depends on both activity and density of cell surface-expressed SERT and 5-HT1A auto-receptors.
|
28528967 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.
|
19829169 |
2009 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression.
|
28920103 |
2017 |