|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The 5-HT1aR/autophagy/p-STAT3 axis influences both tumour cells and immune cells, resulting in immunosuppression in lung adenocarcinomas patients with depression.
|
31009821 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The authors review evidence that altered transcription of the 5-HT1A receptor can affect the serotonin system and limbic and cortical areas, leading to predisposition to depression.
|
15534042 |
2004 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A functional polymorphism in the promoter region of the 5-HT(1A) receptor gene is associated with depression and suicidal behavior.
|
17012696 |
2006 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Behavioral depression was assessed by sucrose preference test (SPT) and the expression of Serotonin 1A (5-HT1A) receptor in the hippocampal.
|
31467884 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that markedly reduced 5-HT1A autoreceptors may provide a marker for aberrant response to SSRI treatment.<b>SIGNIFICANCE STATEMENT</b> Serotonin-selective reuptake inhibitors (SSRIs) are effective in treating anxiety and depression in humans and mouse models.
|
30552180 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL<sub>1</sub>-GAL<sub>2</sub>-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
|
28196617 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression.
|
20025927 |
2010 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenotypes and response to antidepressants is proposed.
|
22826341 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
|
17401528 |
2007 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Consequently, VN2222 is a new compound with a dual effect on the serotonergic system, as 5-HT uptake blocker and 5-HT1A receptor partial agonist, and with a remarkable activity in an animal model of depression with high predictive validity.
|
12020683 |
2002 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recently, modulation of glucocorticoid receptor (GR) and serotonin receptor 1A (5-HTR1A) were implicated in mechanism(s) leading to depression.
|
15885359 |
2005 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
After controlling for sociodemographic and disease-related factors, alexithymia and HTR1A-G polymorphism, both separately (20-22%) and jointly (14-16%), significantly and independently predicted the development of IFN-induced depression.
|
26609890 |
2015 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest an impact of allelic variation in 5-HT(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression.
|
17408646 |
2007 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Depression diagnosis was not associated with MAO-A genotype or 5-HT(1A) receptor availability in these regions.
|
18971477 |
2008 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
ZKHPHP (10 or 20 g/kg) reduced the incidence of depressive-like behaviors and increased HTR1A protein and HTR1A mRNA expression in the hippocampus CA1 in rats displaying depressive behavior, whereas ZKHPHP (3 or 30 g/kg) had no obvious effect on the measured depression indicators.
|
30216226 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Positron emission tomography and post-mortem studies of the number of somatodendritic 5-hydroxytryptamine(1A) (5-HT(1A)) autoreceptors in raphé nuclei have found both increases and decreases in depression.
|
23809646 |
2014 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The measurement of 5-HT1A receptors in drug-naïve schizophrenic patients using the in vivo PET methodology revealed an increase of cortical 5-HT1A receptor binding potential in schizophrenia. beta-CIT as a ligand for measurement of 5-HT transporter densities (5-HTT) revealed lower rates in depression compared to age- and sex-matching healthy controls, a measurement that has also been obtained for bulimia.
|
12478878 |
2002 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present study adds to the clarification of the role of 5-HT1A variation in treatment response in major depression by providing preliminary support for poor treatment response mediated by the 5-HT1A-1019C allele repressing 5-HT1A activity specifically in the melancholic subtype of depression.
|
18387740 |
2008 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Correction: Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.
|
31586041 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression
|
31120232 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT(1A)) subtype, in both disorders.
|
24337875 |
2014 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The 5-HT1A receptor plays a critical role in the pathophysiology of anxiety and depression as well as in the mode of action of anxiolytic and antidepressant drugs.
|
14666415 |
2003 |